Immune modulating therapy to restore impaired innate immunity in patients with sepsis or after surgery

2015 Fiscal Year Final Research Report

• Project/Area Number: 23249072
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: The University of Tokyo
• Principal Investigator: Yamada Yoshitsugu 東京大学, 医学部附属病院, 教授 (30166748)
• Co-Investigator(Kenkyū-buntansha): SETO Yasuyuki 東京大学, 医学部附属病院, 教授 (00260498) ; NAKAJIMA Susumu 東京大学, 医学部附属病院, 准教授 (40323597) ; MATSUBARA Takehiro 東京大学, 医学部附属病院, 特任講師 (40361498) ; CHO Kyohiro 東京大学, 医学部附属病院, 講師 (50302708) ; YAHAGI Naoki 東京大学, 医学部附属病院, 教授 (60158045) ; UCHIDA Kanji 東京大学, 医学部附属病院, 准教授 (60302709) ; YAGI Koichi 東京大学, 医学部附属病院, 助教 (90422310)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 敗血症 / 急性呼吸窮迫症候群 / サイトカイン / 生体防御 / インターフェロンβ / 免疫賦活 / バイオマーカ

Outline of Final Research Achievements

Sepsis and sepsis associated acute respiratory distress syndrome are diseases with high mortality without effective treatment options. Controversies to its pathogenesis and heterogeneity of the patient population are thought to be the failure of multiple clinical trials mainly aims to modulate hyperimmune state.
Retrospective analysis of parameters from patients admitted in the intensive care unit (ICU) in a single institute revealed that lower mean arterial pressure, white blood cell / platelet count, and higher serum lactate dehydrogenase on 1 day after ICU admission associated with in-hospital death. Mouse model of peritoneal sepsis induced by cecal ligation and puncture revealed that septic mice fell into immune compromised state 4-days after CLP and were susceptible to death following nosocomial infection. Systemic interferon beta improved survival of septic pneumonia model and may work to restore impaired innate immunity.

Free Research Field

麻酔学、集中治療医学