Innovative diagnosis and treatment seeds from the two-way analysis of xenograft model by the next generation mass spectrometry

2014 Fiscal Year Final Research Report

• Project/Area Number: 23249073
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kyoto University
• Principal Investigator: OGAWA Osamu 京都大学, 医学(系)研究科(研究院), 教授 (90260611)
• Co-Investigator(Kenkyū-buntansha): KANBA Tomomi 京都大学, 医学研究科, 准教授 (20402836) ; INOUE Takahiro 京都大学, 医学研究科, 講師 (80511881)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 前立腺癌 / 腎癌 / Xenograft / 質量分析 / バイオマーカー / 新規治療標的

Outline of Final Research Achievements

We have established patient-derived tumor tissue(PDTT) xenograft models of urological cancer. Using PDTT xenograft model, we have identified new molecules related with cancer progression and drug resistance by the next generation mass spectrometry. We are planning to evaluate whether these molecules could be biomarker or therapeutic target in clinical setting.

Free Research Field

泌尿器科癌