2013 Fiscal Year Final Research Report
The molecular mechanism of senescence-associated prolongation of inflammatory signaling and its effect on cancer micro-environments.
| Project/Area Number |
23300343
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Carcinogenesis
|
|---|
| Research Institution | Japanese Foundation for Cancer Research |
|---|
Principal Investigator |
OHTANI Naoko 公益財団法人がん研究会, がん研究所, 主任研究員 (50275195)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | 細胞老化 / 炎症性サイトカイン / がん微小環境 / 炎症とがん |
|---|
| Research Abstract |
Cellular senescence is an irreversible cell proliferation arrest provoked by oncogenic impulse such as oncogene activation that creates harmful DNA damage, and is recognized as an important fail-safe mechanism. Recently, it has been reported that senescent cells produce various types of secretory proteins including inflammatory cytokines and chemokines. In this study, we investigated whether this senescence-associated secretory proteins promote cancer progression. We found that senescent hepatic stellate cells (HSCs) form cancer micro-environment in obesity-induced hepatocellular carcinoma tissue. Moreover, we clarified the mechanism of how HSCs senesce and what signal is involved in the production of secretory proteins.
|
-
-
-
[Journal Article] Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome2013
Author(s)
Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N
-
Journal Title
Nature
Volume: 499
Pages: 97-101
-
[Journal Article] Antitumor Impact of p14ARF on Gefitinib-Resistant Non-Small Cell Lung Cancers2013
Author(s)
Saito K, Takigawa N, Ohtani N, Iioka H, Tomita Y, Ueda R, Fukuoka J, Kuwahara K, Ichihara E, Kiura K, Kondo E
-
Journal Title
Mol Cancer Ther
Volume: 12
Pages: 1616-28
-
-
-
-
-
-
-
-
-
-
-
-
