2013 Fiscal Year Final Research Report
The critical role of an inflammatory cytokine IL-1 in tumor microenvironment on regulation of tumor angiogenesis and metastasis
| Project/Area Number |
23300350
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Kyushu University |
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Principal Investigator |
ONO Mayumi 九州大学, 薬学研究科(研究院), 教授 (80128347)
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| Co-Investigator(Renkei-kenkyūsha) |
KAGE Masayoshi 久留米大学, 病理部, 教授 (80148840)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 炎症 / 血管新生 / リンパ管新生 / IL-1 / リンパ節転移 / マクロファージ / VEGF-A / VEGF-C |
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| Research Abstract |
Recently it is highlighted that inflammation is closely linked to tumor progression. In this study we demonstrate that IL-1 promotes tumor angiogenesis and lymphangiogenesis through infiltration of tumor supporting macrophages expressing anigogenic and lymphangiogenic factors, resulting in lymph node metastasis of lung cancer cells by comparing highly metastatic human lung cancer cell line expressing higher IL-1alpha with its low metastatic counterpart expressing lower IL-1alpha. Furthermore, we also demonstrate that IL-1/IL-1R-targeted drug significantly suppresses tumor angiogenesis, lymphangiogenesis, and lymph node metastasis. IL-1/IL-1R may thus play crucial roles in malignant progression by lung cancer cells, and the therapeutic efficacy of IL-1R-targeted drugs may lead to an alternative novel strategy to treat lymph node metastasis.
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