2013 Fiscal Year Final Research Report
Analysis of tumor-rejecting biological reactions induced by tumor specific immune responses
| Project/Area Number |
23300355
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor immunology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 免疫監視 / 腫瘍免疫 / 癌治療 / 免疫エスケープ / NK細胞 / 腫瘍特異的 CTL |
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| Research Abstract |
This study was aiming to reveal the immune responses induced in tumor mass and tumor-rejecting biological responses induced by specific anti-tumor immune responses. I have reported that (1) Critical roles of IFN-gamma produced by primarily infiltrating NK cells for entire anti-tumor immune responses (2) Immune suppression by MHC Class II-dressed NK cells (3) novel therapy basing on the specific phenotypic changes of tumor infiltrating CTLs. I am now going to prepare the reports concerning the mechanisms that immune responses induce resistance against anti-tumor immune responses in targeted-tumor cells and the biological responses specifically induced in the rejected tumor mass.
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