2013 Fiscal Year Final Research Report
Organotin-induced GluR2 decrease and its in vivo neuronal effects
| Project/Area Number |
23310047
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Hiroshima University |
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Principal Investigator |
KOTAKE Yaichiro 広島大学, 医歯薬保健学研究院(薬), 准教授 (20335649)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Shigeru 広島大学, 大学院・医歯薬保健学研究院, 教授 (60160503)
OGRA Yasumitsu 昭和薬科大学, 薬学部, 教授 (40292677)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 有機スズ / グルタミン酸受容体 |
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| Research Abstract |
Environmental concentration of organotins such as tributyltin is close to toxic concentration. In the present study, we examined in vitro mechanism of decrease of GluR2 (an AMPA type glutamate receptor subunit) and its in vivo effects. We clarified that tributyltin suppresses GluR2 expression by decreasing nuclear respiratory factor-1 (NRF-1) activity. Whereas, in in vivo study, GluR2 and brain-derived neurotrophic factor (BDNF) decreased in the cerebral cortex and the hippocampus in tributyltin-treated rats. BDNF is a regulating factor of GluR2 expression. Taken together, GluR2 decrease-induced neurotoxicity might be one of unresolved toxicities.
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[Journal Article] Predictability of metabolism of ibuprofen and naproxen using chimeric mice with human hepatocytes2012
Author(s)
Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Uramaru N, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S
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Journal Title
Drug Metab Dispos
Volume: 40(12)
Pages: 2267-72
DOI
Peer Reviewed
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