Optical Coherence Tomography for Embryology Application

2013 Fiscal Year Final Research Report

• Project/Area Number: 23360026
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied optics/Quantum optical engineering
• Research Institution: Utsunomiya University
• Principal Investigator: YATAGAI Toyohoko 宇都宮大学, オプティクス教育研究センター, 教授 (90087445)
• Co-Investigator(Kenkyū-buntansha): BARRY Cense (90566366)
• Co-Investigator(Renkei-kenkyūsha): MATSUD13 Masaru (20414013)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: OCT / 光干渉断層影像法 / メダカ / 三次元可視化

Research Abstract

Some advanced techniques, such as GFP, enalbe us to make in vivo imaging of biological samples.In this research, an OCT imaging system for 3D imaging of Medaka fish has been developped, by which the eariy state of embriyo and some organs can be imaged without GFP technology. The OCT used in retina imaging is improved to make 3D imaging of moving fish in water.

Research Products

• [Journal Article] Henle fiber layer phase retardation measured with polarization-sensitive optical coherence tomography (2013)
  • Author(s): B.Cense, Q.Wang, S.Lee, L.Zhao, A.E.Elsner, C.Hitzenberger, and D.T.Miller
  • Journal Title: Biomedical Optics Express Volume: 4 (11) Pages: 2296-2306
• [Journal Article] Adaptive optics for optical coherence tomography in retinal imaging: a reflection on past and future developments (2013)
  • Author(s): B.Cense and I.Ibrahim
  • Journal Title: Review of Laser Engineering Volume: 41 (12)
• [Journal Article] Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka (2012)
  • Author(s): Masuyama H, Yamada M, Kamei Y, Fujiwara-Ishikawa T, Todo T, Nagahama Y, Matsuda M
  • Journal Title: Chromosome Res Volume: 20 Pages: 163-76
• [Journal Article] The effect of collimator lenses on the performance of an optical coherence tomography system (2012)
  • Author(s): Pauli Falt, Jakub Czajkowski and Barry Cense
  • Journal Title: Proc. SPIE. Volume: 7885 Pages: 78850X
• [Journal Article] Wide field of view retinal imaging using one-micrometer adaptive optics scanning laser ophthalmoscope (2012)
  • Author(s): Kazuhiro Sasaki, Barry Cense and Yoshiaki Yasuno
  • Journal Title: Proc. SPIE Volume: 7931 Pages: 793106
• [Journal Article] Expression of 3beta-hydroxysteroid dehydrogenase (hsd3b), star and ad4bp/sf-1 during gonadal development in medaka (Oryzias latipes) (2012)
  • Author(s): Nakamoto M, Fukasawa M, Tanaka S, Shimamori K, Suzuki A, Matsuda M, Kobayashi T, Nagahama Y, Shibata N
  • Journal Title: Gen Comp Endocrinol Volume: 176 Pages: 222-230
• [Journal Article] Simultaneous twowavelength Doppler phase-shifting digital holography (2011)
  • Author(s): D.Barada, T.Kiire, J.Sugisaka, S.Kawata, and T.Yatagai
  • Journal Title: Appl. Opt. Volume: 50 Pages: H237-H244
• [Journal Article] Analysis of sexually dimorphic expression of genes at early gonadogenesis of pejerrey Odontesthes bonariensis using a heterologous microarray (2011)
  • Author(s): Fernandino JI, Popesku JT, Paul-Prasanth B, Xiong H, Hattori RS, Oura M, Strussmann CA, Somoza GM, Matsuda M, Nagahama Y, Trudeau VL
  • Journal Title: Sex Dev Volume: 5 Pages: 89-101
• [Presentation] In vivo 3D imaging of medaka fish using SD-OCT for gender differentiation (2014)
  • Author(s): F.M.Gladys, Y.Lim, M.Matsuda, and B.Cense
  • Organizer: Optical Methods in Developmental Biology II, Photonics West BIOS
  • Place of Presentation: San Francisco, California, USA
  • Year and Date: 2014-02-01
• [Presentation] Detection before damage (2013)
  • Author(s): B.Cense
  • Organizer: Biomedical Engineering
  • Place of Presentation: Twente University, Rotterdam Oogziekenhuis, TU Delft, AMC Amsterdam, Radboud Ziekenhuis Nijmegen, the Netherlands
  • Year and Date: 20131007-11
  • Invited
• [Presentation] Non-invasive in vivo 3D imaging of medaka using ultra high resolution spectral domain optical coherence tomography (2013)
  • Author(s): F.M.Gladys, Y.Lim, M.Matsuda, and B.Cense
  • Organizer: 19^<th> Japanese Medaka and Zebrafish Meeting
  • Place of Presentation: Sendai, Japan
  • Year and Date: 20130921-22
• [Presentation] Low cost active retinal tracker for optical coherence tomography (2013)
  • Author(s): Y.Lim, R.de Kinkelder, and B.Cense
  • Organizer: Ophthalmic Technologies XXIII, Photonics West BIOS
  • Place of Presentation: San Francisco, California, USA
  • Year and Date: 20130000
• [Presentation] Full view-angle computer-generated hologram by a fast calculation method based on rigorous diffraction theory (2012)
  • Author(s): Toyohiko Yatagai
  • Organizer: Workshop on Information Optics
  • Place of Presentation: Quebec, Canada
  • Year and Date: 2012-08-20
  • Invited
• [Presentation] High-speed high-resolution polarization-sensitive OCT (2011)
  • Author(s): B.Canse and T.Yatagai
  • Organizer: SPIE
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20110122-27
• [Presentation] 光で生体の断層をみる―光コヒーレンストモグラフィ― (2011)
  • Author(s): 谷田貝豊彦
  • Organizer: 日光シンポジウム
  • Place of Presentation: 日光、栃木県
  • Year and Date: 2011-12-18
  • Invited
• [Patent(Industrial Property Rights)] Device for generating three-dimensional retina image
  • Inventor(s): B.Cense and R.de Kinkelder
  • Industrial Property Rights Holder: 宇都宮大学
  • Industrial Property Rights Type: WO 2013141229 A1
  • Overseas