Implantable gcluose sensor toward fully implantable glucose monitoring system

2015 Fiscal Year Final Research Report

• Project/Area Number: 23360157
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Electron device/Electronic equipment
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: Tokuda Takashi 奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (50314539)
• Co-Investigator(Renkei-kenkyūsha): OHTA Jun 奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (80304161) ; SASAGAWA Kiyotaka 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (50392725) ; NODA Toshihiko 奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (20464159)
• Research Collaborator: TAKEUCHI Shoji 東京大学, 生産技術研究所, 教授 (90343110) ; OKITSU Teru 東京大学, 生産技術研究所, 特任教授 (10378672)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: CMOS / 体内埋め込みデバイス / 血糖値計測 / バイオチップ / 糖尿病

Outline of Final Research Achievements

An implantable glucose sensor was proposed and demonstrated. This sensor is designed based on a concept of fully-implantable glucose monitoring technology. We adopted a glucose-responsive fluorescent hydrogel as a mediator for the implantable glucose sensor. Integrating implantable CMOS imagesensor, fluorescent hydrogel, and mirco-light source (LED) we demonstrated the basic glucose sensing capability. We successfully demonstrated the sensing function in both in vitro and in vivo experiments. We also confirmed a device lifetime longer than 150 days.

Free Research Field

半導体光デバイス・バイオチップ