2013 Fiscal Year Final Research Report
Functional significance of BAG6 in quality control of nascent polypeptides
| Project/Area Number |
23370063
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo Metropolitan University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOKOTA Naoto 首都大学東京, 大学院・理工学研究科, 助教 (40610564)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | BAG6 / ユビキチン / プロテアソーム / タンパク質の品質管理 / 細胞内タンパク質分解 / 分子シャペロン / 新合成ポリペプチド |
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| Research Abstract |
BAG6 (also known as BAT3/Scythe) is a ubiquitin-like protein that is thought to participate in a variety of seemingly unrelated physiological and pathological processes, such as apoptosis, antigen presentation and the T cell response. Recent studies have shown that BAG6 is essential for the quality control of aggregation-prone polypeptide biogenesis. It forms part of a complex that determines the fate of newly synthesized client proteins for membrane insertion, ubiquitin-mediated degradation and/or aggregate formation. A biologically relevant transmembrane protein family has recently been shown to be a major client of BAG6, suggesting that many of the known diverse BAG6 functions can be interpreted by BAG6-mediated control of membrane protein biogenesis. In this project, we investigated the physiological roles of BAG6 with a particular focus on quality control for nascent chain polypeptides.
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Research Products
(44 results)
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[Journal Article] A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 12011
Author(s)
Kagawa, H., Shino, Y., Kobayashi, D., Demizu, S., Shimada. M., Ariga, H. and Kawahara, H
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Journal Title
PLoS ONE
Volume: 6
Pages: e18638
DOI
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[Journal Article] Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p252011
Author(s)
Sato, K., Minegishi, S., Takano, J., Plattner, F., Saito, T., Asada, A., Kawahara, H., Iwata, N., Saido, T.C., and Hisanaga, S.
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Journal Title
J. Neurochem
Volume: 117
Pages: 504-515
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[Presentation] A deubiquitinating enzyme family protein USP18 is implicated in elimination of misfolded proteins by the proteasome2012
Author(s)
Kozawa, H., Kobayashi, T., Endo, A., Tanno, H., Nakamura, N., Bolotbyek, A., Yamamoto, A., Kawahara, H., and Komada, M
Organizer
Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology
Place of Presentation
Kobe International Conference Center
Year and Date
20120528-31
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