Mechanism of selenium-specific chemical transformation in selenoprotein biosynthesis

2015 Fiscal Year Final Research Report

• Project/Area Number: 23380060
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied biochemistry
• Research Institution: Ritsumeikan University
• Principal Investigator: Mihara Hisaaki 立命館大学, 生命科学部, 教授 (30324693)
• Co-Investigator(Renkei-kenkyūsha): TANI Yasushi 立命館大学, 立命館グローバル・イノベーション研究機構, 專門研究員 (90583295) ; SAITO Shigeki 立命館大学, 立命館グローバル・イノベーション研究機構, 專門研究員 (30589908)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: セレン / セレンタンパク質

Outline of Final Research Achievements

This study was conducted to clarify active selenium species that is formed in selenoprotein biosynthesis. We analyzed the detailed reaction of specific transfer of the active selenium species to selenophosphate synthetase. In addition, we focused on the selenium transfer pathway from inorganic selenium, selenite and selenate, to selenoproteins. Enzymes involved in the selenium transfer pathway have been identified, and their structure and function have been characterized.

Free Research Field

応用微生物学・酵素学