2013 Fiscal Year Final Research Report
Preventive effects of marine carotenoids on chronic inflammation-related diseases through regulation of cell and tissue communication
| Project/Area Number |
23380120
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Fisheries chemistry
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
HOSOKAWA Masashi 北海道大学, 大学院水産科学研究院, 准教授 (10241374)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YASUI Yumiko 酪農学園大学, 獣医学部, 准教授 (90434472)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | フコキサンチン / アスタキサンチン / 慢性炎症 / 肥満 / 脂肪組織 / 潰瘍性大腸炎 / ケモカイン / 組織・細胞間相互作用 |
|---|
| Research Abstract |
Fucoxanthin (Fx) suppressed chronic inflammation in white adipose tissue by the inhibition of macrophage and T cell infiltration. Further, Fx down-regulated mRNA expression of chemokines and adipokines, which recruit immune cells and induce insulin resistance. In diabetic/obese mice fed Fx, GLUT4 activation was observed in skeletal muscle through the improvement of hyperglycemia. On the other hand, Fx and astaxanthin (Asx) extracted from H. pluvialis prevent DSS-induced colitis and colon carcinogenesis in mice. In colon of the mice fed Asx, mRNA expression levels of inflammatory cytokines tended to decrease compared to control mice. In addition, Asx down-regulated mRNA expression of inflammatory cytokines in macrophage-like cells and colon cells stimulated by the culture medium of activated macrophages. These results suggest that marine carotenoids prevent chronic inflammation and its-related diseases by the regulation of cell and tissue communication via chemokines and cytokines.
|
