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2013 Fiscal Year Final Research Report

Chemical Biology on the hybrid peptide-induce non-apoptotic cell death

Research Project

  • PDF
Project/Area Number 23390027
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Drug development chemistry
Research InstitutionSojo University

Principal Investigator

KUNIYASU Akihiko  崇城大学, 薬学部, 教授 (90241348)

Co-Investigator(Kenkyū-buntansha) MURATA Kazuyoshi  生理学研究所, 脳機能計測支援センター, 准教授 (20311201)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywordsペプチドミメティックス / 細胞死 / 白血病
Research Abstract

We developed a hybrid peptide, which induces non-apoptotic cell death against leukemia cells. We determined that the mode of the peptide induced cell death is similar to necrosis.
In addition, we newly synthesized a series of the D-amino acid containing-peptide mimetic analogues of the hybrid peptide and evaluated the killing effect on the human leukemic cell lines. These peptides will be a useful tool for development of novel concept-based anti-leukemia agents.

  • Research Products

    (15 results)

All 2014 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (11 results)

  • [Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus2013

    • Author(s)
      Koga Y., Inazato M., Nakamura T., Hashikawa, C., Chirifu M., Michi A., Yamashita T., Toma S., Kuniyasu A., Ikemizu S., Nakabeppu Y., Yamagata Y
    • Journal Title

      Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun

      Volume: 69 Pages: 45-48

    • Peer Reviewed
  • [Journal Article] Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice2012

    • Author(s)
      Kawahara K., Suenobu M., Yoshida A., Koga K., Hyodo A., Ohtsuka H., Kuniyasu A., Tamamaki N., Sugimoto Y., Nakayama H
    • Journal Title

      Neuroscience

      Volume: 207 Pages: 243-260

    • Peer Reviewed
  • [Journal Article] Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression through reactive oxygen species generation and ERK1/2 activation in 3T3-L1 adipocytes2011

    • Author(s)
      Kuniyasu A., Tokunaga T., Yamamoto Y., Inoue S., Obama K., Kawahara K., Nakayama H
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1811 Pages: 153-162

    • Peer Reviewed
  • [Journal Article] Targeting neuropilin-1 in human leukemia and lymphoma2011

    • Author(s)
      Karjalainen K., Jaalouk D.E., Bueso- Ramos C.E., Zurita A.J., Kuniyasu A., Lichtiger B., O'Brien S., Kantarjian H.M., Cortes J.E., Koivunen E., Arap W., Pasqualini R
    • Journal Title

      Blood

      Volume: 117 Pages: 920-927

    • Peer Reviewed
  • [Presentation] ハイブリッドペプチドによる白血病細胞選択的ネクローシス様細胞死の誘導2014

    • Author(s)
      國安明彦, 坂口 隼, 藤川典子, 牧瀬正樹
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本市民総合体育館(熊本県熊本市)
    • Year and Date
      2014-03-28
  • [Presentation] 核膜孔因子Nup50 とNup153 の相互作用とその核内輸送への役割2014

    • Author(s)
      牧瀬正樹, 福永晃祐, 猿渡康宏, 國安明彦
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本市民総合体育館(熊本県熊本市)
    • Year and Date
      2014-03-28
  • [Presentation] Hybrid peptide tat-RAM13 induces a tumor-selective necrosis-like cell death in human leukemic cells2014

    • Author(s)
      Kuniyasu, A., Sakaguchi, H., Makise, M
    • Organizer
      European Association of Cancer Research 2nd Special Conference "Cell Death in Cancer"
    • Place of Presentation
      De Red Hoed (Amsterdam, オランダ国)
    • Year and Date
      2014-01-31
  • [Presentation] 白血病細胞における抗悪性腫瘍ペプチドによるネクローシス様細胞死誘導2013

    • Author(s)
      國安明彦, 牧瀬正樹
    • Organizer
      日本癌学会第71回学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-10-04
  • [Presentation] 核膜孔因子Nup50とNup153 の相互作用とその核内輸送への役割2013

    • Author(s)
      牧瀬正樹, 國安明彦
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-09-11
  • [Presentation] ミクログリア結合ペプチドの生細胞イメージングへの応用2012

    • Author(s)
      村木一徳, 牧瀬正樹, 國安明彦
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2012-12-16
  • [Presentation] 白血病細胞に特異的な非アポトーシス性細胞死の性状解析2012

    • Author(s)
      國安明彦, 中村優希, 藤川典子, 牧瀬正樹
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2012-12-16
  • [Presentation] カスパーゼに依存しない細胞死を誘導する白血病細胞選択的ペプチドミメティク化合物2012

    • Author(s)
      中村優希, 國安明彦
    • Organizer
      日本癌学会第71回学術総会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2012-09-21
  • [Presentation] 脂肪細胞における小粒子LDLによるMCP-1発現増大とその分子機序2012

    • Author(s)
      山田真梨子, 萱島知子, 國安明彦
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2012-03-29
  • [Presentation] A hybrid peptide-25mer induces a caspase-independent cell death in leukemic cell lines2012

    • Author(s)
      Kuniyasu, A., Nishimura, S
    • Organizer
      European Association of Cancer Research Special Conference "Cell Death in Cancer"
    • Place of Presentation
      De Rode Hoed (Amsterdam, オランダ国)
    • Year and Date
      2012-01-26
  • [Presentation] ハイブリッドペプチドが誘導する白血病細胞に対する非アポトーシス細胞死2011

    • Author(s)
      國安明彦
    • Organizer
      日本癌学会第70回学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2011-10-05

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Published: 2015-06-25  

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