2013 Fiscal Year Final Research Report
Effects of early life stress on brain plasticity
| Project/Area Number |
23390040
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Nara Medical University |
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Principal Investigator |
NISHI Mayumi 奈良県立医科大学, 医学部, 教授 (40295639)
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| Co-Investigator(Kenkyū-buntansha) |
AZUMA Cho 奈良県立医科大学, 医学部, 講師 (90326322)
HORII Noriko 奈良県立医科大学, 医学部, 助教 (80433332)
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| Co-Investigator(Renkei-kenkyūsha) |
HAYASHI Yasunori 理化学研究所, シナプス機能研究チーム, チームリーダー (90466037)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 母子分離 / ストレス / c-Fos / コルチコステロイド / 扁桃体延長領域 / 視床下部―下垂体―副腎系 / ペリニューロナルネット / エンドカンナビノイド |
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| Research Abstract |
We investigated effects of early life stress on brain plasticity by using mouse maternal separation (MS), which provides one avenue for delving into the mechanisms mediating interactions between genes and environment. We found that the blood level of stress hormone, corticosterone, increased at adult stage, neuronal activity in the extended amygdala was promoted, and the expression level of several genes regulating learning and memory including endocannabinoid was altered. Furthermore, we observed some behavioral changes such as decrease in aversive memory, motivation for palatable foods in the adulthood.
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[Journal Article] Involvement of SIK3 in glucose and lipid homeostasis in mice2012
Author(s)
Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nishi M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H
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Journal Title
PLoS ONE
Volume: 7
Pages: e37803
Peer Reviewed
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[Journal Article] In vivo assessment of peripheral nerve regeneration by diffusion tensor imaging2011
Author(s)
Morisaki S, Kawai Y, Umeda M, Nishi M, Oda R, Fujiwara H, Yamada K, Higuchi T, Tanaka C, Kawata M, Kubo T
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Journal Title
J of Magn Res Imag
Volume: 33
Pages: 535-542
Peer Reviewed
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