Carbohydrate recognition of B lymphocyte lectins and their function

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390063
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TSUBATA Takeshi 東京医科歯科大学, 難治疾患研究所, 教授 (80197756)
• Co-Investigator(Renkei-kenkyūsha): ITO Nobutoshi 東京医科歯科大学, 難治疾患研究所分子構造情報学分野, 教授 ; WATANABE Kozo 東京医科歯科大学, 難治疾患研究所免疫疾患分野, 助教 (20376718)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: Bリンパ球、 / レクチン / 糖鎖 / 抑制性受容体

Outline of Final Research Achievements

CD72 is an inhibitory receptor expressed mostly in B lymphocytes, and contains a C-type lectin-like domain. We demonstrated that CD72 binds to various sulfated glycans and inhibits immune responses to sulfated glycans. Sulfated glycans are abundantly produced in vertebrates including human, but are not normally produced by microbes. These findings suggest that CD72 recognizes sulfated glycans as a self-associated molecular pattern, and is involved in distinction between self and microbes.

Free Research Field

免疫学