2013 Fiscal Year Final Research Report
Analysis of molecular mechanisms underlying retinal photoreceptor cell fate determination
| Project/Area Number |
23390074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka University (2012-2013)
Osaka Bioscience Institute (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 網膜 / 視細胞 / 網膜変性症 / ノックアウトマウス / 遺伝子制御 |
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| Research Abstract |
In vertebrate retinal development, it has been known that six types of neurons and glial cells (photoreceptors, horizontal cells, bipolar cells, amacrine cells, ganglion cells, and Müller glial cells) are generated from common multipotent progenitor cells. In this developmental process, the gene expression programs controlling retinal development need to be precisely regulated by activating the expression of proper genes and repressing the expression of improper genes. We analyzed the molecular mechanisms underlying this genetic program using mouse molecular genetics. In the current project, we clarified several important mechanisms in cell fate determination, epigenetic regulation, maturation, and survival of photoreceptors. In addition, we developed a gene therapy system using AAV (adenovirus-associated virus), which is a important clue to the suitability of gene therapy for developmental disorders and degeneration of the retina in humans.
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[Journal Article] miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression2011
Author(s)
Sanuki R, Onishi A, Koike C, Muramatsu R, Watanabe S, Muranishi Y, Irie S, Ueno S, Koyasu T, Matsui R, Cherasse Y, Urade Y, Watanabe D, Kondo M, Yamashita T, Furukawa T
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Journal Title
Nat Neurosci
Volume: 14(9)
Pages: 1125-1134
DOI
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[Journal Article] Indentification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction2011
Author(s)
Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T
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Journal Title
PLoS ONE
Volume: 6(5)
Pages: e19911
DOI
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[Presentation] RAX Homeoprotein and NOTCH-HES Signaling Regulate Otx2 Expression in Embryonic Retinal Photoreceptor Cell Fate Determination2012
Author(s)
Takahisa Furukawa , Yuki Muranishi, Koji Terada, Tatsuya Inoue, Kimiko Katoh, Toshinori Tsujii, Rikako Sanuki, Yasuhiro Tamaki
Organizer
ARVO2012
Place of Presentation
Convention Center, Fort Lauderdale, Florida, USA
Year and Date
2012-05-08
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