2013 Fiscal Year Final Research Report
Elucidation of mechanisms of action of the growth factor midkine which is involved in inter-organ crosstalk regulating inflammation and blood pressure
| Project/Area Number |
23390078
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
KADOMATSU Kenji 名古屋大学, 医学(系)研究科(研究院), 教授 (80204519)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEI Yoshifumi 名古屋大学, 医学系研究科, 准教授 (70362233)
KISHIDA Satoshi 名古屋大学, 医学系研究科, 助教 (20402563)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 成長因子 / ミッドカイン / 血圧 / 受容体 |
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| Research Abstract |
The aim of this research is to elucidate midkine (MK) receptor and its downstream signaling by focusing on MK's function in endothelium and inter-organ crosstalk. We developed RNA aptamer and antibody, which strongly inhibited MK binding to the cell as well as tumorigenesis. We also found dynamic expression changes of many molecules including H1FX downstream of MK. Furthermore, we demonstrated that MK-deficient mice did not show hypertension in a model of endothelial injury using a NO synthase inhibitor. The underlying mechanism was that MK suppressed the production of EET which is a candidate EDHF. EDHF is a vasodilator. MK probably suppresses A2AR, which in turn suppresses the activity of CYP450and the production of EET.
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[Journal Article] Midkine overcomes neurite outgrowth inhibition of chondroitin sulfate proteoglycan without glial activation and promotes functional recovery after spinal cord injury2013
Author(s)
Muramoto A, Imagama S, Natori T, Wakao N, Ando K, Tauchi R, Hirano K, Shinjo R, Matsumoto T, Ishiguro N, Kadomatsu K
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Journal Title
Neurosci Lett
Volume: 550
Pages: 150-155
DOI
Peer Reviewed
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[Journal Article] Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis2013
Author(s)
Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K
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Journal Title
Am J Pathol
Volume: 182(2)
Pages: 410-419
DOI
Peer Reviewed
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