2013 Fiscal Year Final Research Report
Mechanistic analysis and prediction of infusion reactions
| Project/Area Number |
23390144
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
SAITO Yoshiro 国立医薬品食品衛生研究所, 医薬安全科学部, 部長 (50215571)
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| Co-Investigator(Kenkyū-buntansha) |
ISHII Akiko 国立医薬品食品衛生研究所, 生物薬品部, 第二室長 (50291117)
KATO Ken 国立がん研究センター, 中央病院, 医長 (50501855)
KUROSE Koichi 国立医薬品食品衛生研究所, 医薬安全科学部, 第三室長 (30280754)
NAKAMURA Ryosuke 国立医薬品食品衛生研究所, 医薬安全科学部, 第三室長 (50333357)
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| Co-Investigator(Renkei-kenkyūsha) |
TADA Minoru 国立医薬品食品衛生研究所, 生物薬品部, 第三室長 (50506954)
SUGIYAMA Emiko 国立医薬品食品衛生研究所, 医薬安全科学部, 第三室非常勤職員 (40574695)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 抗体医薬品 / 副作用 |
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| Research Abstract |
Infusion reaction (IF) is a severe adverse reaction often caused by therapeutic antibodies and occurs at the first time of infusing the antibodies. The mechanistic analysis and prediction of IF in the pre-clinical stage is important for preventing patients from IF in the clinical stage. The results of this study was follows: 1) List of suspected drugs for IF by Japanese Adverse Drug Event Report database. 2) Analysis of FCGR1A, FCGR2A, FCGR3A genes to screen genetic polymorphisms using genomic DNAs from cetuximab-administered patients. 3) Functional analysis of a novel genetic polymorphism 818T>C (L273P) found in FCGR2A gene encoding FcgammaRIIa. 4) Development of in vitro assay system for assessing causability of IF using human peripheral blood mononuclear cells.
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[Journal Article] Genetic polymorphisms of FCGR2A encoding Fcγ receptor IIa in a Japanese population and functional analysis of the L273P variant2012
Author(s)
Tada M, Ishii-Watabe A, Maekawa K, Fukushima-Uesaka H, Kurose K, Suzuki T, Kaniwa N, Sawada J, Kawasaki N, Nakajima TE, Kato K, Yamada Y, Shimada Y, Yoshida T, Ura T, Saito M, Muro K, Doi T, Fuse N, Yoshino T, Ohtsu A, Saijo N, Okuda H, Hamaguchi T, Saito Y, Matsumura Y
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Journal Title
Immunogenetics
Volume: 64
Pages: 869-877
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