2013 Fiscal Year Final Research Report
Increases in Tryptophan-kynurenine pathway metabolism following interferon-induced depression
| Project/Area Number |
23390149
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
SAITO KUNIAKI 京都大学, 医学(系)研究科(研究院), 教授 (80262765)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yasuko 京都大学, 大学院・医学研究科, 助教 (00331869)
MURAKAMI Yuki 京都大学, 大学院・医学研究科, 研究員 (50580106)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | サイトカイン / インターフェロン / トリプトファン / IDO / 抑うつ / ウイルス性肝炎 |
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| Research Abstract |
Increases in L-tryptophhn (TRP) to L-kynurenine (KYN) pathway metabolism were found in interferon (IFN) treated-HCV patients with depressive symptoms. Further, mice with Interferon (IFN) gene transfection induced indoleamine 2,3-dioxygenase (IDO1) , resulting marked increase in TRP to KYN pathway metabolites, which well correlated with depression. The blockade of IDO1 activation prevented the development of depressive-like behavior.
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[Journal Article] Kynurenine production mediated by indoleamine 2, 3-dioxygenase aggravates liver injury in HBV-specific CTL-induced fulminant hepatitis2014
Author(s)
Ohtaki H, Ito H, Ando K, Ishikawa T, Hoshi M, Ando T, Takamatsu M, Hara A, Moriwaki H, Saito K, Seishima M
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Journal Title
DOI
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[Journal Article] Effects of indoleamine 2, 3-dioxygenase deficiency on high-fat diet-induced hepatic inflammation2013
Author(s)
Nagano J, Shimizu M, Hara T, Shirakami Y, Kochi T, Nakamura N, Ohtaki H, Ito H, Tanaka T, Tsurumi H, Saito K, Seishima M, Moriwaki H
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Journal Title
PLoS One
Volume: 9;8(9)
Pages: e73404
DOI
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[Journal Article] IDO1 plays an immunosuppressive role in 2, 4, 6-trinitrobenzene sulfate-induced colitis in mice2013
Author(s)
Takamatsu M, Hirata A, Ohtaki H, Hoshi M, Hatano Y, Tomita H, Kuno T, Saito K, Hara A
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Journal Title
J Immunol
Volume: 15;191(6)
Pages: 3057-64
DOI
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[Journal Article] Epigallocatechin gallate inhibits the expression of indoleamine 2, 3-dioxygenase in human colorectal cancer cells2012
Author(s)
Ogawa K, Hara T, Shimizu M, Nagano J, Ohno T, Hoshi M, Ito H, Tsurumi H, Saito K, Seishima M, Moriwaki H
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Journal Title
Oncol Lett
Volume: 4(3)
Pages: 546-550
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[Journal Article] Inhibition of increased indoleamine 2, 3-dioxygenase activity attenuates Toxoplasma gondii replication in the lung during acute infection2012
Author(s)
Murakami Y, Hoshi M, Hara A, Takemura M, Arioka Y, Yamamoto Y, Matsunami H, Funato T, Seishima M, Saito K
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Journal Title
Cytokine
Volume: 59(2)
Pages: 245-51
DOI
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[Journal Article] L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice2012
Author(s)
Hoshi M, Matsumoto K, Ito H, Ohtaki H, Arioka Y, Osawa Y, Yamamoto Y, Matsunami H, Hara A, Seishima M, Saito K
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Journal Title
J Immunol
Volume: 15;188(8)
Pages: 3980-7
DOI
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[Presentation] Labdane-type diterpene, constituent from myoga which are traditional Japanese food inhibit enzyme activity and gene expression of in doleamine 2, 3-dioxygenase 12013
Author(s)
Imai, R Yamamoto, Y Yamamoto, Y Katayan agi, R Fukutomi, M Abe, Y Ozawa, K Saito
Place of Presentation
Milan, Italy
Year and Date
20130822-27
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[Book] Tumor Necrosis factor
Author(s)
Murakami Y, Imamura Y, Mitani S, Hoshi M, Arioka Y, Yamamoto Y, Seiyama A, Saito K
Publisher
Nova Science Publishers, Inc
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