2013 Fiscal Year Final Research Report
Examination of the pathogenesis of epigenetics of virus infection for allergic diseases and development of preventive methods for it
Project/Area Number |
23390160
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hygiene
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HITOMI Yoshiaki 金沢大学, 医学系, 准教授 (70231545)
KAMBAYASHI Yasuhiro 金沢大学, 医学系, 講師 (20345630)
SUGANUMA Narufumi 高知大学, 医歯学系, 教授 (50313747)
FUKUTOMI Yuma 独立行政法人国立病院機構(相模原病院臨床研究センター), 診断・治療薬開発研究室, 室長 (30463110)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Keywords | アレルギー / エピジェネティクス / RSウイルス / 妊娠 / メチル化 / 感作 / アレルゲン / 分子疫学 |
Research Abstract |
The infection of virus such as respiratory syncytial virus is involved in pathogenesis of allergy during prenatal and postnatal infants, although the interaction between candidate genes and virus infection remains to be elucidated. We demonstrated hypomethylation of CpG islands produced by virus infection in IL4RA gene in splenic cells for postpartum infants from pregnant model mouse. Epidemiologic study showed the hypomethylation of CpG islands in in IL4RA gene in monocytes in cord blood of pregnant patients with asthma sensitized by house dust. These results suggest expression of IL4RA gene in just new born infants is produced by infection of RS virus.
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Research Products
(54 results)
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[Journal Article] Antipsychotics for delirium in the general hospital setting in consecutive 2453 inpatients : a prospective observational study2014
Author(s)
Hatta K, Kishi Y, Wada K, Odawara T, Takeuchi T, Shiganami T, Tsuchida K, Oshima Y, Uchimura N, Akaho R, Watanabe A, Taira T, Nishimura K, Hashimoto N, Usui C, Nakamura H
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Journal Title
Int J Geriatr Psychiatry
Volume: 29(3)
Pages: 253-262
DOI
Peer Reviewed
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[Journal Article] The possibility that requiring high-dose olanzapine cannot be explained by pharmacokinetics in the treatment of acute-phase schizophrenia2013
Author(s)
Hatta K, Takebayashi H, Sudo Y, Katayama S, Kasuya M, Shirai Y, Morikawa F, Nakase R, Nakamura M, Ito S, Kuga H, Nakamura M, Ohnuma T, Usui C, Nakamura H, Hirata T, Sawa Y, for the JAST study group
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Journal Title
Psychiatry Res
Volume: 210(2)
Pages: 396-401
DOI
Peer Reviewed
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[Journal Article] Vulnerability to traumatic stress in fibromyalgia patients : 19 months follow-up after the Great East Japan Disaster2013
Author(s)
Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Itoh K, Yamano Y, Nakamura H, Asukai N, Nakajima T, Nishioka K
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Journal Title
Arthritis Research & Therapy
Volume: 15(5)
Pages: R130
DOI
Peer Reviewed
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[Journal Article] The Japanese version of the modified ACR preliminary diagnostic criteria for fibromyalgia and the fibromyalgia symptom scale : reliability and validity2013
Author(s)
Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Itoh K, Yamano Y, Nakamura H, Nakajima T, Nishioka K
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Journal Title
Mod Rheumatol
Volume: 23(5)
Pages: 846-850
DOI
Peer Reviewed
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[Journal Article] Epidemiological study on the involvements of environmental factors and allergy in child mental health using autism spectrum questionnaire2013
Author(s)
Shibata A, Hitomi Y, Kambayashi Y, Hibino Y, Yamazaki M, Mitoma J, Asakura H, Hayashi K, Otaki N, Sagara T, Nakamura H
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Journal Title
Res Autism Spectr Disord
Volume: 7(1)
Pages: 132-140
DOI
Peer Reviewed
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[Journal Article] Decreased activity of daily living produced by the combination of Alzheimer's disease and lower limb fracture in elderly requiring nursing care2013
Author(s)
Inagawa T, Hamagishi T, Takaso Y, Hitomi Y, Kambayashi Y, Hibino Y, Shibata A, Ngoc NT, Okochi J, Hatta K, Takamuku K, Konoshita T, Nakamura H
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Journal Title
Environ Health Prev Med
Volume: 18
Pages: 16-23
DOI
Peer Reviewed
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[Journal Article] Cellular Heat Acclimation Regulates Cell Growth, Cell Morphology, Mitogen-activated Protein Kinase Activation, and Expression of Aquaporins in Mouse Fibroblast Cells2012
Author(s)
Sugimoto N, Shido O, Matsuzaki K, Ohno-Shosaku T, Hitomi Y, Tanaka M, Sawaki T, Fujita Y, Kawanami T, Masaki Y, Okazaki T, Nakamura H, Koizumi S, Yachie A, Umehara H
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Journal Title
Cell Physiol Biochem
Volume: 30(2)
Pages: 450-457
DOI
Peer Reviewed
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[Journal Article] A comparison between augmentation with olanzapine and increased risperidone dose in acute schizophrenia patients showing early non-response to risperidone2012
Author(s)
Hatta K, Otachi T, Sudo Y, Kuga H, Takebayashi H, Hayashi H, Ishii R, Kasuya M, Hayakawa T, Morikawa F, Hata K, Nakamura M, Usui C, Nakamura H, Hirata T, Sawa Y, For the JAST study group
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Journal Title
Psychiatry Res
Volume: 198(2)
Pages: 194-201
DOI
Peer Reviewed
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[Journal Article] Obesity and aspirin intolerance are risk factors for difficult-to-treat asthma in Japanese non-atopic women2012
Author(s)
Fukutomi Y, Taniguchi M, Tsuburai T, Tanimoto H, Oshikata C, Ono E, Sekiya K, Higashi N, Mori A, Hasegawa M, Nakamura H, Akiyama K
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Journal Title
Clin Exp Allergy
Volume: 42(5)
Pages: 738-746
DOI
Peer Reviewed
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[Journal Article] The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor α chain gene between atopic dermatitis and Japanese cedar pollinosis2012
Author(s)
Tanaka T, Hitomi Y, Kambayashi Y, Hibino Y, Fukutomi Y, Shibata S, Sugimoto S, Hatta K, Eboshida A, Konoshita T, Nakamura H
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Journal Title
Allergol Int
Volume: 61(1)
Pages: 57-63
DOI
Peer Reviewed
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[Journal Article] Clinical relevance of IgE to recombinant Gly m 4 in the diagnosis of adult soybean allergy2012
Author(s)
Fukutomi Y, Sjölander S, Nakazawa T, Borres MP, Ishii T, Nakayama S, Tanaka A, Taniguchi M, Saito A, Yasueda H, Nakamura H, Akiyama K
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Journal Title
J Allergy Clin Immunol
Volume: 129(3)
Pages: 860-863
DOI
Peer Reviewed
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[Journal Article] The Japanese version of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and the Fibromyalgia Symptom Scale : reliability and validity2012
Author(s)
Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Ito K, Yamano Y, Nakamura H, Nakajima T, Nishioka K
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Journal Title
Mod Rheumatol
Volume: 22(1)
Pages: 40-44
DOI
Peer Reviewed
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[Journal Article] Anti-inflammatory effects of sacran, a novel polysaccharide from Aphanothece sacrum, on 2, 4, 6-trinitrochlorobenzene-induced allergic dermatitis in vivo2012
Author(s)
Ngatu NR, Okajima MK, Yokogawa M, Hirota R, Eitoku M, Muzembo BA, Dumavibhat N, Takaishi M, Sano S, Kaneko T, Tanaka T, Nakamura H, Suganuma N
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Journal Title
Ann Allergy Asthma Immunol
Volume: 108(2)
Pages: 117-122
DOI
Peer Reviewed
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[Journal Article] Association between Body Mass Index and Asthma among Japanese Adults : Risk within the Normal Weight Range2012
Author(s)
Fukutomi Y, Taniguchi M, Nakamura H, Konno S, Nishimura M, Kawagishi Y, Okada C, Tanimoto Y, Takahashi K, Akasawa A, Akiyama K
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Journal Title
Int Arch Allergy Immunol
Volume: 157(3)
Pages: 281-287
DOI
Peer Reviewed
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[Journal Article] Phosphodiesterase Inhibitors Suppress Lactobacillus casei Cell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A-or Exchange Protein Activated by cAMP-Dependent Signal Pathway2012
Author(s)
Saito T, Sugimoto N, Ohta K, Shimizu T, Ohtani K, Nakayama Y, Nakamura T, Hitomi Y, Nakamura H, Koizumi S, Yachie A
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Journal Title
The Scientific World Journal
Volume: 2012
Pages: 748572
DOI
Peer Reviewed
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[Journal Article] Time trend in the prevalence of adult asthma in Japan : Findings from population-based surveys in Fujieda City in 1985, 1999, and 20062011
Author(s)
Fukutomi Y, Taniguchi M, Watanabe J, Nakamura H, Komase Y, Ohta K, Akasawa A, Nakagawa T, Miyamoto T, Akiyama K
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Journal Title
Allergol Int
Volume: 60(4)
Pages: 443-448
DOI
Peer Reviewed
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[Presentation] アスピリンが好塩基球のIgE 依存的活性化に及ぼす影響2013
Author(s)
堀井雅恵, 福冨友馬, 東馬智子, 東朋美, 北岡政美, 三苫純子, 朝倉大貴, 神林康弘, 人見嘉哲, 谷内江昭宏, 中村裕之
Organizer
第20回日本免疫毒性学会学術大会
Place of Presentation
東海大学代々木キャンパス(東京都)
Year and Date
2013-09-13
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[Presentation] 児の精神的健康に関連する食行動の疫学研究2012
Author(s)
柴田亜樹, 人見嘉哲, 神林康弘, 日比野由利, 朝倉大貴, 三苫純子, 山崎政美, 大滝直人, 林宏一, 大西孝司, 相良多喜子, 中村裕之
Organizer
第22回体力・栄養・免疫学会大会
Place of Presentation
いこいの村 能登半島(石川県
Year and Date
2012-08-26
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[Presentation] 要介護高齢者におけるアルツハイマー疾患と骨折の合併による生活動作能力の低下2012
Author(s)
稲川利光, 濱岸利夫, 人見嘉哲, 神林康弘, 日比野由利, 山崎政美, 朝倉大貴, 三苫純子, 柴田亜樹, 木戸康人, 中村剛, 能登裕幸, 久保良美, 中村裕之
Organizer
第22回体力・栄養・免疫学会大会
Place of Presentation
いこいの村 能登半島(石川県)
Year and Date
2012-08-25
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[Presentation] 志賀町健康調査における一般住民の疾患とADL の関連2012
Author(s)
山崎政美, 人見嘉哲, 朝倉大貴, 三苫純子, 柴田亜樹, 神林康弘, 日比野由利, 四蔵直人, 宇野文夫, 和田隆志, 中村裕之
Organizer
第22回体力・栄養・免疫学会大会
Place of Presentation
いこいの村 能登半島(石川県)
Year and Date
2012-08-25
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[Presentation] 高齢者における慢性疼痛と日常生活動作(ADL)の低下に関する疫学研究2012
Author(s)
三苫純子, 人見嘉哲, 朝倉大貴, 山崎政美, 柴田亜樹, 神林康弘, 日比野由利, 四蔵直人, 宇野文夫, 和田隆志, 中村裕之
Organizer
第22回体力・栄養・免疫学会大会
Place of Presentation
いこいの村 能登半島(石川県)
Year and Date
2012-08-25
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[Presentation] 黄砂による慢性咳嗽の症状への影響2012
Author(s)
東朋美, 神林康弘, 藤村政樹, 吉崎智一, 西條清史, 早川和一, 人見嘉哲, 小林史尚, 道上義正, 中村裕之
Organizer
第82回日本衛生学会学術総会
Place of Presentation
京都大学吉田キャンパス(京都府)
Year and Date
2012-03-25
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[Presentation] アレルギー発症予防フィルターの開発2012
Author(s)
弘田量二, Muzembo Basilua, 中村裕之, 栄徳勝光, Narongpon Dumavibhat, Ngatu Nlandu Roger, 菅沼成文
Organizer
第82回日本衛生学会学術総会
Place of Presentation
京都大学吉田キャンパス(京都府)
Year and Date
2012-03-25
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