Evaluation of arginase as an inflammatory biomarker.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23390163
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Okayama University
• Principal Investigator: OGINO Keiki 岡山大学, 医歯(薬)学総合研究科, 教授 (70204104)
• Co-Investigator(Kenkyū-buntansha): WANG Da-hong 岡山大学, 大学院・医歯薬学総合研究科, 講師 (90294404) ; TAKAHASHI Hidekazu 山口大学, 大学院・医学系研究科, 講師 (90450402) ; KUBO Masayuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60420519) ; OUCHI Kazunobu 川崎医科大学, 医学部, 教授 (80351899) ; OBASE Yasushi 川崎医科大学, 医学部, 講師 (40399762) ; MATSUI Hideki 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30157234)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 予防医学 / アレルギー / アルギナーゼ / バイオマーカー / 喘息 / 糖尿病 / 肥満

Research Abstract

The availability of arginase as a biomarker for asthma, diabetes, and obesity was evaluated. In asthmatic patients, the relationship among arginase and physiological factors was investigated using a multivariable analysis. Given that the concentration of serum arginase had a positive correlation with hs-CRP, exhaled nitric oxide, NOx, and 3-nitrotyrosine, it is likely that arginase is available as a biomarker. In obese model mice, the expression of arginase was upregulated, in proportion as increase of body weight and blood glucose. Nitrite may contribute to prevention of diabetes, because the concentration of insulin was downregulated with nitrite.

Research Products

• [Journal Article] Associations of serum retinol, α-tocopherol, and γ-tocopherol with biomarkers among healthy Japanese men (2014)
  • Author(s): Zou Y, Wang DH, Sakano N, Sato Y, Iwanaga S, Taketa K, Kubo M, Takemoto K, Masatomi C, Inoue K, Ogino K
  • Journal Title: International Journal of Environmental Research and Public Health Volume: Vol.11 Pages: 1647-1660
  • DOI: 10.3390/ijerph110201647
  • Peer Reviewed
• [Journal Article] Association of serum arginase I with L-arginine, 3-nitrotyrosine, and exhaled nitric oxide in healthy Japanese worker (2014)
  • Author(s): Ogino K, Wang DH, Kubo M, Obase Y, Setiawan H, Yan F, Takahashi H, Zhang R, Tsukiyama Y, Yoshida J, Zou Y
  • Journal Title: Free Radical Research Volume: Vol. 48 Pages: 137-145
  • DOI: 10.3109/10715762.2013.842979
  • Peer Reviewed
• [Journal Article] Evaluation of serum arginase I as an oxidative stress biomarker in a healthy Japanese population using a newly established ELISA (2013)
  • Author(s): Ogino K, Murakami I, Wang DH, Tsukiyama Y, Takahashi H, Kubo M, Sakano N, Setiawan H, Bando M, Ohmoto Y
  • Journal Title: Clinical Biochemistry Volume: Vol. 46 Pages: 1717-1722
  • DOI: 10.1016/j.clinbiochem.2013.08.012
  • Peer Reviewed
• [Journal Article] omparison of serum ferritin and oxidative stress biomarkers between Japanese workers with and without metabolic syndrome (2013)
  • Author(s): Iwanaga S, Sakano N, Taketa K, Takahashi N, Wang DH, Takahashi H, Kubo M, Miyatake N, Ogino K
  • Journal Title: Obesity Research & Clinical Practice Volume: (in press)
  • DOI: 10.1016/j.orcp.2013.01.003
  • Peer Reviewed
• [Journal Article] Relationship between ceruloplasmin and oxidative biomarkers including ferritin among healthy Japanese (2013)
  • Author(s): Inoue K, Sakano N, Ogino K, Sato Y, Wang DH, Kubo M, Takahashi H, Kanbara S, Miyatake N
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: Vol. 52 Pages: 160-166
  • DOI: 10.3164/jcbn.12-122
  • Peer Reviewed
• [Journal Article] Evaluation of urinary hydrogen peroxide as an oxidative stress biomarker in a healthy Japanese population (2013)
  • Author(s): Sato Y, Ogino K, Sakano N, Wang DH, Yoshida J, Akazawa Y, Kanbara S, Inoue K, Kubo M, Takahashi H
  • Journal Title: Free Radical Research Volume: Vol. 47 Pages: 181-191
  • DOI: 10.3109/10715762.2012.759218
  • Peer Reviewed
• [Journal Article] Inhibition of arginase ameliorates experimental ulcerative colitis in mice (2013)
  • Author(s): Akazawa Y, Kubo M, Zhang R, Matsumoto K, Yan F, Setiawan H, Takahashi H, Fujikura Y, Ogino K
  • Journal Title: Free Radical Research Volume: Vol. 47 Pages: 137-145
  • DOI: 10.3109/10715762.2012.756980
  • Peer Reviewed
• [Journal Article] Anti-inflammatory effect of arginase inhibitor and corticosteroid on airway allergic reactions in a Dermatophogoides farinae-induced NC/Nga mouse model (2013)
  • Author(s): Ogino K, Kubo M, Takahashi H, Zhang R, Zou Y, Fujikura Y
  • Journal Title: Inflammation Volume: Vol. 36 Pages: 141-151
  • DOI: 10.1007/s10753-012-9529-3
  • Peer Reviewed
• [Journal Article] Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury (2012)
  • Author(s): Imagama T, Ogino K, Takemoto K, Kato Y, Kataoka H, Suzuki H, Ran Z, Setiawan H, Fujikura Y, Taguchi T
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: Vol. 51 Pages: 68-75
  • DOI: 10.3164/jcbn.D-11-00011
  • Peer Reviewed
• [Journal Article] Inflammatory airway responses by nasal inoculation of suspended particulate matter in NC/Nga mice (2012)
  • Author(s): Ogino K, Takahashi N, Kubo M, Takeuchi A, Nakagiri M, Fujikura Y
  • Journal Title: Environmental Toxicology Volume: (in press)
  • DOI: 10.1002/tox.21791
  • Peer Reviewed
• [Presentation] 男性労働者における血中抗酸化ビタミンと血中バイオマーカーとの関連性について (2013)
  • Author(s): 鄒宇, 汪達紘, 坂野紀子, 佐藤美恵, 久保正幸, 竹本圭, 荻野景規
  • Organizer: 第57回中国四国合同産業衛生学会
  • Place of Presentation: 香川県社会福祉総合センター (香川)
  • Year and Date: 2013-12-08
• [Presentation] 職業従事者におけるストレスに関するスコアと生活習慣及び血液バイオマーカーとの関連性についての検討 (2013)
  • Author(s): 三宅優紀, 高橋秀和, 久保正幸, 汪達紘, 佐藤美恵, 吉田純子, 張燃, 築山依果, 鄒宇, 舟久保徳美, 叶欽霞, 石井香代子, 井上清美, 荻野景規
  • Organizer: 第86回日本産業衛生学会学術総会
  • Place of Presentation: ひめぎんホール (愛媛)
  • Year and Date: 2013-05-17
• [Presentation] 肥満マウスモデルにおける血中アルギナーゼ活性およびアルギニン量の変化 (2013)
  • Author(s): 高橋秀和, 中田信也, 張燃, ヘリ・セティアワン, 村上育郎, 久保正幸, 荻野景規
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢大学 鶴間キャンパス (石川)
  • Year and Date: 2013-03-25
• [Presentation] 企業従事者における抗酸化炎症バイオマーカーセルロプラスミンに関する研究 (2012)
  • Author(s): 井上清美, 坂野紀子, 佐藤美恵, 汪達紘, 久保正幸, 高橋秀和, 宮武伸行, 荻野景規
  • Organizer: 第56回中国四国合同産業衛生学会
  • Place of Presentation: 岡山大学 創立五十周年記念館 (岡山)
  • Year and Date: 2012-12-09
• [Presentation] 企業健診受診者における酸化ストレスバイオマーカーと動脈硬化および冠動脈疾患リスクについて (2012)
  • Author(s): 佐藤美恵, 荻野景規, 坂野紀子, 汪達紘, 吉田純子, 赤澤裕二, 神原咲子, 井上清美, 久保正幸, 高橋秀和
  • Organizer: 第56回中国四国合同産業衛生学会
  • Place of Presentation: 岡山大学 創立五十周年記念館 (岡山)
  • Year and Date: 2012-12-09
• [Presentation] セルロプラスミンは抗酸化炎症バイオマーカーの一種か? (2012)
  • Author(s): 井上清美, 坂野紀子, 佐藤美恵, 久保正幸, 汪達紘, 高橋秀和, 宮武伸行, 荻野景規
  • Organizer: 第10回日本予防医学会学術総会
  • Place of Presentation: 広島大学 霞キャンパス広仁会館 (広島)
  • Year and Date: 2012-11-25
• [Presentation] 健診受診者における尿中過酸化水素について (2012)
  • Author(s): 佐藤美恵, 荻野景規, 坂野紀子, 汪達紘, 吉田純子, 赤澤裕二, 神原咲子, 井上清美, 久保正幸, 高橋秀和
  • Organizer: 第10回日本予防医学会学術総会
  • Place of Presentation: 広島大学霞キャンパス広仁会館 (広島)
  • Year and Date: 2012-11-25
• [Presentation] 新しい炎症性バイオマーカー『アルギナーゼI』と酸化ストレス (2012)
  • Author(s): 荻野景規
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都大学 吉田キャンパス (京都)
  • Year and Date: 2012-03-25
• [Presentation] 呼気NO とその調節因子 (2011)
  • Author(s): 荻野景規
  • Organizer: 第3回日本安定同位体・生体ガス医学応用学会大会
  • Place of Presentation: 東邦大学医療センター大森病院5 号館地下1 階臨床講堂 (東京)
  • Year and Date: 2011-11-04
• [Presentation] 健康成人及び喘息患者における血清3-nitrotyrosine の疫学的評価 (2011)
  • Author(s): 荻野景規, 高橋紀子, ヘリ・セティアワン, 赤澤裕二, 高橋秀和, 汪達紘
  • Organizer: 第17回MPO 研究会シンポジウム
  • Place of Presentation: アークホテル熊本(熊本)
  • Year and Date: 2011-10-28
• [Book] Studies on Pediatric Disorders (Chapter Title : Analytical Procedures for Nitrative/Nitrosative Stress) (2014)
  • Author(s): Kubo M and Ogino K
  • Publisher: Springer(in press)