2013 Fiscal Year Final Research Report
The role of lymphatic system and its functional failure in development of metabolic disorders.
| Project/Area Number |
23390185
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Chiba University |
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Principal Investigator |
YOKOTE Koutaro 千葉大学, 大学院医学研究院, 教授 (20312944)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEMOTO Minoru 千葉大学, 大学院・医学研究院, 准教授 (60447307)
FUJIMOTO Masaki 千葉大学, 医学部附属病院, 助教 (20451742)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 生活習慣病 / リンパ管 / 糖尿病 |
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| Research Abstract |
The aim of this study is to detect the contribution of lymphatic vessels to lifestyle related disease.In obese type2 diabetic mice,pancreatic lymphatic vasculature was increased and VEGF-C expression was enhanced in islets.In vitro study showed that IL-1beta and TNF-alpha upregulated VEGF-C in pancreatic alpha cells and pancreatic beta cells.These results indicated that in diabetes and obesity,elevated inflammatory cytokine induce VEGF-C expression in islets,thereby pancreatic lymphatic vessels were increased.
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[Journal Article] Distinct Roles for CXCR6+ and CXCR6- CD4+ T Cells in the Pathogenesis of Chronic Colitis2013
Author(s)
Mandai Y, Takahashi D, Hase K, Obata Y, Furusawa Y, Ebisawa M, Nakagawa T, Sato T, Katsuno T, Saito Y, Shimaoka T, Yokosuka O, Yokote K, Ohno H
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Journal Title
PloS One
Volume: 8(6)
Pages: e65488
DOI
Peer Reviewed
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[Journal Article] LR11 : a novel biomarker identified in follicular lymphoma2013
Author(s)
Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
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Journal Title
Br J Haematol
Volume: 163(2)
Pages: 277-280
DOI
Peer Reviewed
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[Journal Article] Angiotensin II Type 1 Receptor Blocker Prevents Renal Injury via Inhibition of the Notch Pathway in Ins2 Akita Diabetic Mice2012
Author(s)
Koshizaka M, Takemoto M, Sato S, Tokuyama H, Fujimoto M, Okabe E, Ishibashi R, Ishikawa T, Tsurutani Y, Onishi S, Mezawa M, He P, Honjo S, Ueda S, Saito Y, Yokote K
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Journal Title
Exp Diabetes Res
Pages: 159874
DOI
Peer Reviewed
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[Journal Article] Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis2011
Author(s)
Takeda Y, Nakaseko C, Tanaka H, Takeuchi M, Yui M, Saraya A, Miyagi S, Wang C, Tanaka S, Ohwada C, Sakaida E, Yamaguchi N, Yokote, K., Hennighausen L, Iwama A
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Journal Title
Br J Haematol
Volume: 153, 5
Pages: 589-598
DOI
Peer Reviewed
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[Journal Article] The roles of transforming growth factor-b and Smad3 signaling in adipocyte differentiation and obesity2011
Author(s)
Tsurutani Y, Fujimoto M, Takemoto M, Irisuna H, Koshizaka M, Ohnishi S, Ishikawa T, He P, Honjo S, Maezawa Y, Saito Y, Yokote, K
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Journal Title
Biochem Biophys Res Commun
Volume: 1;407(1)
Pages: 68-73
DOI
Peer Reviewed
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