2013 Fiscal Year Final Research Report
Senescence-inducing stress modulates glycolysis and the Warburg effect
| Project/Area Number |
23390186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kyoto University |
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Principal Investigator |
KONDOH Hiroshi 京都大学, 医学(系)研究科(研究院), 助教 (80402890)
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| Co-Investigator(Kenkyū-buntansha) |
YOKODE Masayuki 京都大学, 医学研究科, 教授 (20252447)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Koji 国立がん研究センター研究所, 室長 (80342913)
SOGA Tomoyoshi 慶応大学, 環境情報学部, 教授 (60338217)
TAKAORI Akifumi 京都大学, 医学研究科, 教授 (20324626)
TANAKA Tomoaki 千葉大学, 医学部, 講師 (50447299)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 老化 / 老年医学 / 解糖系代謝 / 癌化 |
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| Research Abstract |
Our main concern is the senescence-bypassing effect of PGAM, glycolytic enzyme. We reported that PGAM is ubiquitinated by oncogene Mdm2 under senescence-inducing stress(Mikawa et al JCB 2014). We also identified HNF-1 as transcriptional regulator for glycolysis in ovarian cancer(Okamoto et al, Molecu Carci 2013). We reported PGAM impairs mitochondrial respiration in vivo(Okuda et al, PLOSONE 2013). We also found that PGAM is acetyalted in cancer cells. And We finally generated PGAM-TG mice. We also reported transforming ability of MEFs from PGAM-TG (Mikawa et al JCB 2014). Thus we disclosed unknown aspect of the Warburg effect through molecular investigation of PGAM.
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[Journal Article] Senescence-inducing stress promotes proteolysis of glycolytic enzyme phosphoglycerate mutase via ubiquitin ligase Mdm22014
Author(s)
T Mikawa, T Maruyama, K Okamoto, H Nakagama, ME LLeonart, T Tsusaka, K Hori, I Murakami, T Izumi, A T-Kondo, M Yokode, G Peters, D Beach, & H Kondoh
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Journal Title
Journal of Cell Biology
Volume: 204(5)
Pages: 729-45
DOI
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[Journal Article] Hepatocyte nuclear factor-1β promotes glucose uptake and glycolytic activity in ovarian clear carcinoma2013
Author(s)
T Okamoto, M Mandai, N Matsumura, K Yamaguchi, H Kondoh, Y Amano, T Baba, J Hamanishi, K Abiko, K Kosaka, S K, Murphy, S Mori, I Konishi
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Journal Title
DOI
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[Journal Article] Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice2013
Author(s)
Okuda J, Niizuma S, Shioi T, Kato T, Inuzuka Y, Kawashima T, Tamaki Y, Kawamoto A, Tanada Y, Iwanaga Y, Narazaki M, Matsuda T, Adachi S, Soga T, Takemura G, Kondoh H, Kita T, Kimura T
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Journal Title
PLoS One
Volume: 8(8)
Pages: e72173
DOI
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[Journal Article] Impact of COPD exacerbations on osteoporosis assessed by chest CT scan2012
Author(s)
H Kiyokawa, S Muro, T Oguma, S Sato, N Tanabe, T Takahashi, M Kudo, D Kinose, H Kondoh, T Kubo, Y Hoshino, E Ogawa, T Hirai, and M Mishima
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Journal Title
COPD
Volume: 9
Pages: 1-8
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