2013 Fiscal Year Final Research Report
Pathophysiological mechanisms in sarcopenic obesity
| Project/Area Number |
23390188
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Ehime University |
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Principal Investigator |
KOHARA Katsuhiko 愛媛大学, 医学(系)研究科(研究院), 准教授 (30260384)
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| Co-Investigator(Kenkyū-buntansha) |
MOGI Masaki 愛媛大学, 大学院・医学系研究科, 准教授 (20363236)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 内臓肥満 / サルコペニア / 動脈スティフネス / 機能障害 / 代謝異常 / アディポカイン |
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| Research Abstract |
We proposed the definition of sarcopenia and sarcopenic obesity. Three aspects of sarcopenic obesity, 1) metabolic abnormality, 2) functional change, and 3) causality, were investigated.
1) Metabolic abnormality; Sarcopenic obesity is associated with insulin resistance, leptin resistance, and adiponectin paradox. Sarcopenia is also involved in the BNP resistance observed in obese subjects.
2) Functional changes; Sarocopenia was related to frailty, arterial stiffness, central blood pressure and end organ damages. 3)Causalty; Several candidate genes for sarcopenia were identified including KCNQ1 and CHD13. We demonstrated ectopic fat infiltration in the skeletal muscle in cardiotoxin injury model of ob/ob and KKAy mouse. Causal relationship between sarcopenic obesity and cardiovascular events will be followed in longitudinal study.
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Research Products
(18 results)
