2013 Fiscal Year Final Research Report
Development of cell-based therapy using dedifferentiated fat cells for treatment of intractable diseases in elderly patients
| Project/Area Number |
23390190
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANO Koichiro 日本大学, 生物資源科学部, 教授 (80271039)
NORO Chikako 日本大学, 生産工学部, 教授 (80311356)
ISHIGE Mika 日本大学, 医学部, 助教 (90420950)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 老年医学 / 再生医療 / 脂肪細胞 |
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| Research Abstract |
We evaluated the therapeutic effect and safety of dedifferentiated fat (DFAT) cell transplantation in animal models of diseases, mainly occur in elderly people. Autologous implantation of DFAT cells significantly improved blood flow and vascular density in a rabbit and a porcine model of hindlimb ischemia. Autologous DFAT cell transplantation also contributed to bone regeneration in a rabbit bone defect model and an ovariectomy-induced osteoporosis model. Tumor formation or abnormal cell differentiation was not observed in any animal that received DFAT cell transplantation. These results suggest that DFAT cell transplantation is a safe and useful strategy for treatment of intractable diseases in elderly patients.
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