2013 Fiscal Year Final Research Report
Organ crosstalk and chronic inflammation in the pathogenesis of cardiovascular diseases
| Project/Area Number |
23390203
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MANABE Ichiro 東京大学, 医学部附属病院, 講師 (70359628)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIU Katsuhito 東京大学, 医学部附属病院, 特任助教 (30422306)
MATSUMOTO Sahohime 東京大学, 医学部附属病院, 特任助教 (80570184)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | メタボリックシンドローム / 心不全 / 臓器連関 / 慢性炎症 / 脂肪酸 |
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| Research Abstract |
In this project we analyzed how chronic inflammation that is initiated in obese adipose tissue affects the cardiovascular system in metabolic syndrome. We found that saturated fatty acids that are released from obese adipose tissue promote inflammation in the cardiovascular system ("fat-heart, fat-vessel crosstalk"). We also found that the heart and kidneys interact with each other in response to cardiac stress, and this interaction ("cardiorenal crosstalk") is important for the maintenance of cardiac homeostasis.
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[Journal Article] Saturated fatty acid palmitate aggravates neointima formation by promoting smooth muscle phenotypic modulation2013
Author(s)
Shen H, Eguchi K, Kono N, Fujiu K, Matsumoto S, Shibata M, Oishi-Tanaka Y, Komuro I, Arai H, Nagai R, Manabe I
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Journal Title
Atertiosclerosi, Thrombosis, and Vascular Biology
Volume: 33
Pages: 2596-2607
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[Journal Article] Saturated Fatty Acid and TLR Signaling Link b Cell Dysfunction and Islet Inflammation2012
Author(s)
Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R
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Journal Title
Cell Metabolism
Volume: 15
Pages: 518-533
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