2013 Fiscal Year Final Research Report
Elucidation of the cardiovascular disease by the innovative three-dimensional proteome analytical method
| Project/Area Number |
23390204
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUZUKI Toru 東京大学, 医学部附属病院, 准教授 (90359620)
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| Co-Investigator(Kenkyū-buntansha) |
AIZAWA Kenichi 東京大学, 医学部附属病院, 特任助教 (70436484)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 循環器・高血圧 / 蛋白質 / プロテオーム / ストレス / ﾄﾗﾝｽﾚｰｼｮﾅﾙ･ﾘｻｰﾁ |
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| Research Abstract |
We analyzed innovative three-dimensional proteome in consideration of the diachronic analysis that was necessary for the elucidation of the cardiovascular disease in this study. We performed the bioactive examination based on methodology of the disease proteome analysis about a disease-related factor and checked participation in disease condition of a patient. Our initial clinical experience shows that it is strongly associated with presence of restenosis. Reduced levels of the amino-terminal processed peptide, BNP(5-32), relative to BNP(3-32) (as the index parameter BNP[5-32]/BNP[3-32] ratio), were seen in patients with restenosis. In addition, we added examination about the generation mechanism of this disease-related factor and got the knowledge that certain protease participated in. We will consider what kind of activity this protease has in blood and will aim at the condition of a patient elucidation of the cardiovascular disease in future.
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[Journal Article] Inverse correlations between serum ADAMTS13 levels and systolic blood pressure, pulse pressure, and serum C-reactive protein levels observed at a general health examination in a Japanese population : a cross-sectional study2013
Author(s)
Enokoku K, Ikeda H, Kato R, Kume Y, Yoshida H, Ono T, Aizawa K, Suzuki T, Yamzaki T, Yatomi Y
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Journal Title
Clin. Chim. Acta
Volume: 421
Pages: 147-151
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