2013 Fiscal Year Final Research Report
Elucidation of inflammatory network underlying the pathogenesis of atrial fibrillation
| Project/Area Number |
23390213
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo (2013)
Osaka University (2011-2012) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOMURO Issei 東京大学, 医学系研究科, 教授 (30260483)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 分子心臓病態学 / 肥満細胞 / リモデリング / スタチン |
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| Research Abstract |
Endothelin-1 (ET-1) is profoundly involved in the activation of mast cells in hemodyamically stressed atria. ET-1-induced secretion of monocyte chemotactic protein-1 (MCP-1) from activated mast cells enhances migration of macrophages, and consequently promotes atrial remodeling. HMG-CoA reductase pitavastatin inhibits ET-1-triggered activation of mast cells and up-regulation of fibrogenic PDGF-A in atria, and thereby prevents atrial remodeling and inducibility of atrial fibrillation. These results suggest that application of statins may be a promising approach to achieve upstream prevention of atrial fibrillation in stressed hearts.
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[Journal Article] Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system2013
Author(s)
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang, L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T.
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Journal Title
Hypertension
Volume: 61
Pages: 341-351
Peer Reviewed
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[Journal Article] Notch activation mediates angiotensin II-induced vascular remodeling by promoting proliferation and migration of vascular smooth muscle cells2013
Author(s)
Ozasa Y, Akazawa H, Qin Y, Tateno K, Ito K, Kudo-Sakamoto Y, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Minamino T, Nagai T, Kobayashi Y, Komuro I
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Journal Title
Hypertens Res
Volume: 36
Pages: 859-865
Peer Reviewed
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[Journal Article] High incidence of Aggregatibacter actinomycetemcomitans infection in patients with cerebral infarction and diabetic renal failure : A cross-sectional study2013
Author(s)
Murakami M, Suzuki J, Yamazaki S, Ikezoe M, Matsushima R, Ashigaki N, Aoyama N, Kobayashi N, Wakayama K, Akazawa H, Komuro I, Izumi Y, Isobe M
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Journal Title
BMC Infect Dis
Volume: 13
Pages: 557
Peer Reviewed
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[Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in co-cultured adipocytes2012
Author(s)
Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 302
Pages: E286-296
Peer Reviewed
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[Journal Article] Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice2012
Author(s)
Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Paradis P, Nemer M, Komuro I
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Journal Title
Hypertension
Volume: 59
Pages: 627-633
Peer Reviewed
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[Journal Article] Complement C1 q activates canonical Wnt signaling and promotes aging-related phenotypes2012
Author(s)
Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I
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Journal Title
Cell
Volume: 149
Pages: 1298-1313
Peer Reviewed
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[Journal Article] Ryanodine receptor type 2 is required for the development of pressure overload-induced cardiac hypertrophy2011
Author(s)
Zou Y, Liang Y, Zhou N, Ma H, Guan A, Gong H, Sun A, Wang P, Niu Y, Jiang H, Takano H, Toko H, Yao A, Takeshima H, Akazawa H, Shiojima I, Wang Y, Komuro I, Ge J
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Journal Title
Hypertension
Volume: 58
Pages: 1099-110
Peer Reviewed
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[Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011
Author(s)
Fukushima N, Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, Seki A, Murasaki KM, Shimizu T, Yamato M, Okano T, Kasanuki H, Hagiwara N, Komuro I
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Journal Title
PLoS ONE
Volume: 6
Pages: e27901
Peer Reviewed
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