2015 Fiscal Year Final Research Report
A novel treatment strategy for inflammatory lung diseases, using de-differentiation mechanisms toward bronchiolar stem cells
| Project/Area Number |
23390219
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Niigata University (2015)
Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HATTORI Koichi 東京大学, 医科学研究所, 准教授 (10360116)
OHKOUCHI Shinya 東北大学, 大学院医学系研究科, 講師 (40375035)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | 幹細胞 |
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| Outline of Final Research Achievements |
Based on our finding that secretory leukocyte protease inhibitor (SLPI) was involved in differentiative switches between bronchiolar stem cells and differentiated lung cells, we investigated the downstream signals of SLPI. As a result, we identified a molecule that induced de-differentiation to bronchiolar stem cells in the signaling pathway of SLPI, and hereafter referred to it as bronchiolar progenitor factor (BPF). Administration of recombinant BPF protein ameliorated naphthalene-induced lung inflammation. These results suggest that the differentiative switches between bronchiolar stem cells and differentiated lung cells may be a useful target to develop a novel strategy for inflammatory lung diseases.
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| Free Research Field |
呼吸器内科学
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