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2014 Fiscal Year Final Research Report

Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse

Research Project

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Project/Area Number 23390221
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionOkayama University

Principal Investigator

KIURA Katsuyuki  岡山大学, 大学病院, 教授 (10243502)

Co-Investigator(Kenkyū-buntansha) TKIGAWA Nagio  川崎医科大学, 医学部, 教授 (60325107)
HOTTA Katsuyuki  岡山大学, 大学病院, 講師 (70379816)
Co-Investigator(Renkei-kenkyūsha) TAKATA Minoru  京都大学, 放射線生物研究センター, 教授 (30281728)
NAKABEPPU Yusaku  九州大, 学生体防御医学研究所, 教授 (30180350)
YOSHINO Tadashi  岡山大学, 医薬歯学総合研究科, 教授 (70183704)
Project Period (FY) 2011-04-01 – 2015-03-31
KeywordsEGFR遺伝子改変マウス / afatinib / everolimus (mTOR阻害薬), / JAK-1/2 inhibitors / cetuximab / bevacizumab / Ogg1ホモノックアウトマウス / NNK
Outline of Final Research Achievements

① Using the EGFR genetically modified mice, afatinib (irreversible TKI), everolimus (mTOR inhibitor), and AZD1480 (JAK-1/2 inhibitors) revealed an anti-tumor effect. ②In mouse xenograft models, afatinib + cetuximab + bevacizumab combination therapy against resistant cells harbouring T790M has proved to result in lasting pathologic complete response. ③ Although 9.3% of Ogg1 (-/-) homozygous knockout mice to a high dose of tobacco-specific nitrosamines (NNK) had adenocarcinoma of the lung, it is not recognized carcinogenesis at low doses. The relationship between epidermal growth factor receptor (EGFR) gene mutations and NNK-induced carcinogenesis was unclear.

Free Research Field

呼吸器内科学(胸部腫瘍学)

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Published: 2016-06-03  

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