2012 Fiscal Year Final Research Report
Discovery of a novel inter-organ metabolic communication system
| Project/Area Number |
23390238
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
KATAGIRI Hideki 東北大学, 大学院・医学系研究科, 教授 (00344664)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 糖尿病 / 肥満 / 脳・神経 / 脂質代謝 |
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| Research Abstract |
We have found that adaptive thermogenesis induced by brown adipose tissue (BAT) was markedly suppressed, when hepatic glucose metabolism was enhanced by glucokinase overexpression. This liver-to-BAT communication is mediated by a neuronal relay consisting of afferent vagal and efferent sympathetic nerves. This inter-tissue system seems to function as a feed-forward mechanism favoring energy storage. This mechanism might have worked advantageously under conditions of repetitive excesses and shortagesof food. Unfortunately, however, in the current age of constant plenty, this system seems to trigger obesity development. In fact, we further found that this system contributes to determining obesity predisposition among murine strains.
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Research Products
(36 results)
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[Journal Article] Chronic mild stress alters circadian expressions ofmolecular clock genes in the liver2012
Author(s)
Takahashi K, Yamada T, Tsukita S, Kaneko K, Shirai Y, Munakata Y, Ishigaki Y, Imai J, Uno K, Hasegawa Y, Sawada S, Oka Y, Katagiri H.
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 304(3)
Pages: E301-E309
DOI
Peer Reviewed
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[Journal Article] Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals2012
Author(s)
Tsukita S, Yamada T, Uno K, Takahashi K, Kaneko K, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, Ishihara H, Oka Y, Katagiri H.
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Journal Title
Cell Metab
Volume: 16(6)
Pages: 825-832
DOI
Peer Reviewed
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[Journal Article] Importance of endothelial NF-κB signaling in vascular remodeling and aortic aneurysm formation2012
Author(s)
Saito T, Hasegawa Y, Ishigaki Y, Yamada T, Gao J, Imai J, Uno K, Kaneko K, Ogihara T, Shimosawa T, Asano T, Fujita T, Oka Y, Katagiri H.
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Journal Title
Cardiovascular Research
Volume: 97(1)
Pages: 106-114
DOI
Peer Reviewed
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[Journal Article] Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-medeiated pathway2012
Author(s)
Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I, Nojima A, Ito T, Yoshida Y, Kobayashi Y, Katagiri H, Minamino T, Komuro I
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32(8)
Pages: 1902-9
DOI
Peer Reviewed
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[Journal Article] Blockade of the Nuclear Factor-κB Pathway in the Endothelium Prevents Insulin Resistance and Prolongs Life Spans2012
Author(s)
Hasegawa Y, Saito T, Ogihara T,Ishigaki Y, Yamada T, Imai J, Uno K, Gao J, Kaneko K, Shimosawa T, Asano T, Fujita T, Oka Y, Katagiri H
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Journal Title
Circulation
Volume: 125
Pages: 1122-1133
DOI
Peer Reviewed
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[Journal Article] Hepatic peroxisome proliferator-activatedreceptor-{gamma}-fat-specificprotein 27 pathway contributes to obesity-related hypertension via afferent vagal signals2011
Author(s)
Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Gao J, Kaneko K, Matsusue K, Yamazaki T, Oka Y, Katagiri H
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Journal Title
Eur Heart J
Volume: 33
Pages: 1279-1289
DOI
Peer Reviewed
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[Journal Article] Increased systemic glucose tolerance with increased muscle glucose uptake in transgenic mice overexpressing RXRγ in skeletal muscle2011
Author(s)
Sugita S, Kamei Y, Akaike F, Suganami T, Kanai S, Hattori M, Manabe Y, Fujii N, Takai-Igarashi T, Tadaishi M, Oka J, Aburatani H, Yamada T, Katagiri H, Kakehi S, Tamura Y, Kubo H, Nishida K, Miura S, Ezaki O, Ogawa Y.
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Journal Title
PLoS One
Volume: 6(5)
Pages: e20467
DOI
Peer Reviewed
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[Journal Article] Involvement of Endoplasmic Stress Protein C/EBP Homologous Protein in Arteriosclerosis Acceleration With Augmented Biological Stress Responses2011
Author(s)
Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J, Uno K, HasegawaY, Sawada S, Ishihara H, Oyadomari S, Mori M, Oka Y, Katagiri H.
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Journal Title
Circulation
Volume: 124(7)
Pages: 830-9
DOI
Peer Reviewed
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[Presentation] Bach 1 dificiency protects pancreatic bepa cells from oxidative stress injury2012
Author(s)
Kondo K, Ishigaki Y, Gao J, Yamada T, Imai J, Sawada S, Muto A, Oka Y,Igarashi K, Katagiri H.
Organizer
48th European Association for the Study of Diabetes Annual Meeting
Place of Presentation
Berlin,Germany
Year and Date
20121001-05
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[Presentation] 褐色脂肪組織における熱産生調節につながる組織間ネットワーク2012
Author(s)
突田壮平,山田哲也,宇野健司,高橋圭,浅井洋一郎,白井勇太,宗像佑一郎,金子慶三,澤田正二郎,長谷川豊,今井淳太,石垣泰,岡芳知,片桐秀樹
Organizer
第55回日本糖尿病学会年次学術集会
Place of Presentation
横浜
Year and Date
20120517-19
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