2013 Fiscal Year Final Research Report
Establishment of personalized immunotherapy method for virus-infected diseases using lymphocyte chip
| Project/Area Number |
23390264
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Infectious disease medicine
|
|---|
| Research Institution | University of Toyama |
|---|
Principal Investigator |
MURAGUCHI Atsushi 富山大学, 大学院医学薬学研究部(医学), 教授 (20174287)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KISHI Hiroyuki 富山大学, 大学院・医学薬学研究部(医学), 准教授 (60186210)
OZAWA Tatsuhiko 富山大学, 大学院・医学薬学研究部(医学), 助教 (10432105)
KITAJIMA Isao 富山大学, 大学院・医学薬学研究部(医学), 教授 (50214797)
NIKAIDO Toshio 富山大学, 大学院・医学薬学研究部(医学), 教授 (50180568)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | 感染症 / リンパ球チップ / 免疫治療 / 抗体遺伝子 / TCR遺伝子 |
|---|
| Research Abstract |
Recently, the emerging and re-emerging infectious diseases such as avian flu and AIDS, and other opportunistic or latent infectious diseases are threatening human beings. Immunotherapy via virus-specific monoclonal antibody and cytotoxic T cells is the most likely candidate to treat these fearful infectious diseases. We had developed a novel and innovative method, called "lymphocyte chip", to isolate human antigen-specific antibody-secreting cells from peripheral blood of patients with infectious diseases. In this research, we improved the lymphocyte chip method to clone efficiently and rapidly (within 10 days) antigen specific-antibody or TCR genes from individual lymphocytes of virus-infected patients as well as cancer patients, which may facilitate personalized immunotherapy for infectious diseases as well as cancer.
|
Research Products
(47 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] A novel human TCR efficient cloning system confers candidate for TCR gene therapy within 10 days2012
Author(s)
Kobayashi E., Mizukoshi E., Kishi H., Hamana H., Nagai T ., Ozawa T., Nakagawa H., Jin A., Kaneko S., and Muraguchi A
Organizer
27th Annual Meeting of Society for Immunotherapy of Cancer
Place of Presentation
North Bethesda, USA
Year and Date
20121026-28
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
