2013 Fiscal Year Final Research Report
Functional develpment of 5-HT/GABA neurons in the raphe nuclei - postnatal stress and epigenetics
| Project/Area Number |
23390284
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IZUMI Takeshi 北海道大学, 医学研究科, 講師 (60312360)
YOSHIDA Takayuki 北海道大学, 医学研究科, 助教 (60374229)
OHMURA Yu 北海道大学, 医学研究科, 助教 (80597659)
KAWATO Suguru 東京大学, 大学院・総合文化研究科, 教授 (50169736)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 精神薬理学 |
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| Research Abstract |
It is known that child abuse is a risk factor for depression. To elucidate the mechanisms and to develop the treatments are required. Rats were subjected to aversive foot shock (FS) during the third week of the postnatal period (3wFS
group). 3wFS group displayed depressive-like behavior in adulthood and showed the increased protein levels of tryptophan hydroxylase 2 in the dorsal raphe nucleus which is a origin of serotonergic neurons. These adverse effects were partly reversed by repeated administration of selective serotonin reuptake inhibitor (SSRI). Thus, it is possible that SSRI administration could partly attenuate the adverse effects of child abuse.
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