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2013 Fiscal Year Final Research Report

Research and development in the continuous variable SOBP irradiation method as a new irradiation method

Research Project

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Project/Area Number 23390308
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

NISHIO Teiji  独立行政法人国立がん研究センター, 臨床開発センター, ユニット長 (40415526)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Keiichi  東京大学, 医学部附属病院, 准教授 (80188896)
Co-Investigator(Renkei-kenkyūsha) KOIZUMI Tetsuo  立教大学, 理学部, 教授 (90147926)
ASO Tsukasa  富山高等専門学校, 専攻科, 教授 (30290737)
OZAWA Shuuichi  広島大学, 大学院・医歯薬保健学研究院, 特任准教授 (20360521)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords放射線治療物理学 / 荷電重粒子線照射技術
Research Abstract

In this study, proton therapy for cancer with high precision can be provided by research and development in the continuous variable SOBP irradiation method as a new irradiation method.
Proton beam irradiated using the method is adjusted so it would fit the size of patient tumor. Irradiation system where uniform depth-dose distributions can be formed to fit the size of patient tumor by controlling synchronization between continuous proton beam provided by a cyclotron accelerator for clinical proton therapy and rotational position of a rotary range modulator wheel is completed. To verify whether proton irradiation to a tumor is performed precisely, three systems were developed which are the plastic scintillation detector system, calculation system of dose distribution using images considering human respective composition, and calculation system of activity distribution for visible monitoring. We integrated the three systems and examined its total performance.

  • Research Products

    (23 results)

All 2014 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (14 results) (of which Invited: 1 results) Book (4 results)

  • [Journal Article] Impact of flattening-filter-free techniques on delivery time for lung stereotactic volumetric modulated arc therapy and image quality of concurrent kilovoltage cone-beam computed tomography : a preliminary phantom study2014

    • Author(s)
      Nakagawa K, Haga A, Sakumi A, Yamashita H, Igaki H, Shiraki T, Ohtomo K, Iwai Y, Yoda K
    • Journal Title

      J Radiat Res

      Volume: 55(1) Pages: 200-202

    • Peer Reviewed
  • [Journal Article] Study of dose-volume delivery guided proton therapy2013

    • Author(s)
      T. Nishio, K. Matsushita, M. Sekine, S. Nakamura, S. Tanaka, A. Miyatake
    • Journal Title

      J. J. Radiol. Tech

      Volume: 69(11) Pages: 1297-1305

    • Peer Reviewed
  • [Journal Article] Application of activity pencil beam algorithm using measured distribution data of positron emitter nuclei for therapeutic SOBP proton beam2013

    • Author(s)
      A. Miyatake, T. Nishio
    • Journal Title

      Med. Phys

      Volume: 40(9) Pages: 091709-1-9

    • Peer Reviewed
  • [Journal Article] Experimental evaluation of a spatial resampling technique to improve the accuracy of pencil-beam dose calculation in proton therapy2012

    • Author(s)
      Y. Egashira, T. Nishio, T. Matsuura, S. Kameoka, M. Uesaka
    • Journal Title

      Med. Phys

      Volume: 39(7) Pages: 4104-4114

    • Peer Reviewed
  • [Journal Article] Extension of the Particle Therapy Simulation Framework to Hospital Information Systems and Multi-grid Environments2012

    • Author(s)
      T. Aso, Y. Maeda, G. Iwai, W. Takase, T. Sasaki, Y. Watase, T. Yamashita, T. Akagi and Y. Nakano
    • Journal Title

      IEEE International Conference on Computational Science and Engineering

      Pages: 229-234

    • Peer Reviewed
  • [Presentation] Built in online-PET system of Sumitomo proton therapy system2013

    • Author(s)
      M. Yamada, D. Amano, T. Tachikawa, H. Nonaka, T. Nishio
    • Organizer
      ACCAPP 2013
    • Place of Presentation
      Bruges, Belgium
    • Year and Date
      20130805-08
  • [Presentation] Development of beam scanning control system for proton radiation therapy2013

    • Author(s)
      J. Inoue, T. Ochi, T. Morita, T. Tachikawa, T. Asaba, R. Kohno, K. Hotta, Y. Matsuzaki, T. Nishio, T. Akimoto
    • Organizer
      PTCOG 52
    • Place of Presentation
      Essen, Germany, Congress Center
    • Year and Date
      20130602-08
  • [Presentation] "陽子線治療におけるPETイメージング", 合同シンポジウム3-医学物理におけるイノベイティブテクノロジー2013

    • Author(s)
      西尾禎治
    • Organizer
      日本医学物理学会第105回学術大会
    • Place of Presentation
      横浜, 神奈川, パシフィコ横浜
    • Year and Date
      20130411-14
    • Invited
  • [Presentation] 陽子線治療における体内中での標的原子核破砕反応の研究2013

    • Author(s)
      松下慶一郎, 西尾禎治, 玉木聖一, 稲庭拓, 野口綾太, 鈴木龍彦, 中村哲志, 川端麻莉子, 杉浦彰則
    • Organizer
      日本医学物理学会第105回学術大会
    • Place of Presentation
      横浜, 神奈川, パシフィコ横浜
    • Year and Date
      20130411-14
  • [Presentation] 標的原子核破砕反応と高精度陽子線がん治療に関する研究2013

    • Author(s)
      西尾禎治, 松下慶一郎, 関根雅晃, 宮武彩
    • Organizer
      日本物理学会第68回年次大会
    • Place of Presentation
      東広島, 広島大学
    • Year and Date
      20130326-29
  • [Presentation] A Study of Multiplex Proton Imaging Using GEANT42012

    • Author(s)
      T.Aso, K.Kawashima, T.Nishio, S.B.Lee, T.Sasaki
    • Organizer
      IEEE Nuclear Science Symposium
    • Place of Presentation
      Anaheim, California
    • Year and Date
      20121029-1103
  • [Presentation] 深部方向の線量測定簡便化装置の開発2012

    • Author(s)
      中村哲志, 淺井博之, 秋田峻吾, 上窪純史, 青山結樹, 横澤淳司, 須釜裕也, 武居秀行, 西尾禎治, 丸山浩一, 早川和重
    • Organizer
      日本医学物理学会第104回学術大会
    • Place of Presentation
      筑波, つくば国際会議場
    • Year and Date
      20120914-15
  • [Presentation] Performace of beam ON-LINE PET system constructed with two opposing planar-type detector heads in proton therapy2012

    • Author(s)
      T. Nishio, A. Miyatake, K. Matsushita, M. Sekine
    • Organizer
      The 31st Sapporo International Cancer Symposium / Advanced Radiation Therapy and Cancer Research Up-to-Date
    • Place of Presentation
      Sapporo, Hokkaido University
    • Year and Date
      20120723-24
  • [Presentation] 陽子線連続可変SOBP照射法のプロトタイプ装置の開発2012

    • Author(s)
      西尾禎治, 江頭祐亮, 阿蘇司, 小澤修一, 小泉哲夫, 中川恵一
    • Organizer
      日本医学物理学会第103回学術大会
    • Place of Presentation
      横浜, パシフィコ横浜
    • Year and Date
      20120412-15
  • [Presentation] 高感度マイクロチャンネルプレートの絶対検出効率測定2012

    • Author(s)
      守屋宗祐, 的場史朗, 小泉哲夫, 城丸春夫
    • Organizer
      日本物理学会第67回年次大会
    • Place of Presentation
      関西学院大学
    • Year and Date
      20120324-27
  • [Presentation] Proton treatment planning system in National Cancer Center Hospital East2011

    • Author(s)
      T. Nishio
    • Organizer
      The 6th JSMP-KSMP/11th AOCMP Meeting
    • Place of Presentation
      Fukuoka
    • Year and Date
      20110929-1001
  • [Presentation] Spatial re-sampling of pencil beams to improve the dose-calculation accuracy in proton therapy2011

    • Author(s)
      Y. Egashira, T. Nishio, T. Matuura, S. Kameoka, M. Uesaka
    • Organizer
      2011 Joint AAPM/COMP Meeting
    • Place of Presentation
      Canada (Vancouver)
    • Year and Date
      20110731-0804
  • [Presentation] A GEANT4 Based Particle Therapy Simulation Framework2011

    • Author(s)
      T.Aso, A.Kumura, T.Yamashita, T.Akagi, S.Kameoka, T.Nishio, K.Murakami, C.Omachi, T.Sasaki, K.Amako, H.Yoshida, H.Kurashige
    • Organizer
      PTCOG 50
    • Place of Presentation
      America (Philadelphia)
    • Year and Date
      20110512-14
  • [Presentation] 陽子線治療におけるON-LINE PET2011

    • Author(s)
      西尾禎治
    • Organizer
      第10回化学放射線科学研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-18
  • [Book] 図解診療放射線技術実践ガイド第3版, 第3章放射線治療技術:陽子線治療2014

    • Author(s)
      遠藤啓吾編集主幹, 西尾禎治
    • Total Pages
      1084
    • Publisher
      文光堂
  • [Book] 医学物理の理工学-下巻-2013

    • Author(s)
      上坂充, 中川恵一, 西尾禎治, 金井達明
    • Total Pages
      274
    • Publisher
      養賢堂
  • [Book] 医学物理の理工学-上巻-2012

    • Author(s)
      上坂充, 中川恵一, 西尾禎治, 金井達明
    • Total Pages
      255
    • Publisher
      養賢堂
  • [Book] 臨床放射線腫瘍学-最新知見に基づいた放射線治療の実践-2012

    • Author(s)
      日本放射線腫瘍学会, 日本放射線腫瘍学研究機構
    • Total Pages
      534
    • Publisher
      南江堂

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Published: 2015-06-25  

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