2013 Fiscal Year Final Research Report
Establishment of non-invasive cancer screening paradigm
| Project/Area Number |
23390323
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤原 俊義 , 医歯(薬)学総合研究科, 教授 (00304303)
八木 孝仁 大学病院, 教授 (00304353)
貞森 裕 , 医歯(薬)学総合研究科, 准教授 (30362974)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | がん検診 / メチル化DNA |
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| Outline of Final Research Achievements |
In this study, we developed a new extremely simple procedure of detecting methylated DNA in the 8 CpGs regions in human DNA recovered from very small quantity of feces and sputum.Moreover, the procedure easily modifies the cut-off value suitable for various conditions for screening not only people with lung and colorectal cancer but also other gastrointestinal cancers.
Our technology could provide a possibility of building an effective medical screening strategy. Additionally, we searched for biomarkers of various cancer leading to accumulation of very important knowledge and discover new seeds, affected not only cancer diagnostic paradigm but also cancer treatment system.
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| Free Research Field |
外科系臨床医学
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