Functional analysis of a set of genes related to the molecular targeted therapy resistance in glioblastoma and the development of novel therapeutic strategies

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390343
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: The University of Tokyo
• Principal Investigator: MUKASA Akitake 東京大学, 医学部附属病院, 講師 (90463869)
• Co-Investigator(Kenkyū-buntansha): SAITO Kuniaki 杏林大学, 医学部, 助教 (50446564) ; TANAKA Minoru 東京大学, 医学部付属病院, 助教 (50332581)
• Research Collaborator: OHTANI Rhyohei ; OMATA Mayu
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 膠芽腫 / 分子標的治療 / 治療耐性 / EGFR / 腫瘍幹細胞

Outline of Final Research Achievements

Molecular targeted therapy against epidermal growth factor receptor (EGFR）had been tested for malignant gliomas (glioblastomas), however, the efficacy was limited since the tumors rapidly became resistant to the targeted therapy. In this study, we analyzed the function of a set of resistance-related genes that we identified in the previous study and called “SDeltaE” (the substitute for Delta EGFR expression). Some of candidate SDletaE genes were revealed to be upregulated in glioma-initiating cells. Inhibition of these SDeltaE led to suppression of tumor cell growth and invasion. Hence, these genes were expected be the novel targets in malignant gliomas.

Free Research Field

悪性脳腫瘍