Quantitative evaluation system for severity of osteoarthritis

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390356
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: MURAKI Shigeyuki 東京大学, 医学部附属病院, 准教授 (40401070)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Noriko 東京大学, 医学部附属病院, 特任准教授 (60240355) ; AKUNE Toru , 国立障害者リハビリテーションセンター, 副院長 (60282662) ; OKA Hiroyuki 東京大学, 医学部附属病院, 特任助教 (60401064)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: コホート / 医療・福祉 / 老化 / 疫学 / 国際比較

Outline of Final Research Achievements

We have developed software to measure joint space width, osteophyte area, and other parameters of osteoarthritis of the knee, lumbar spine, and hip. Strict international comparisons regarding osteoarthritis can be made by using this software. In the present study, international comparative studies between the ROAD study in Japan (3,040 participants) and the Chingford study in the United Kingdom (1,353 participants) were performed, and references for joint space width, osteophyte area, and other parameters of osteoarthritis were established. In addition, we found that joint space width was narrower and osteophyte area at the knee was larger in subjects in Japan than in those in the United Kingdom. We also found that not only joint space narrowing but also osteophytosis at the knee had a significant effect on ADL and QOL , and that dietary factors and occupational activities had a significant impact on joint space narrowing and osteophytosis.

Free Research Field

整形外科、運動器疫学