一般住民コホートの全脊椎MRI検診データを用いた脊椎疾患のエビデンス解明

2011 Fiscal Year Annual Research Report

• Project/Area Number: 23390357
• Research Institution: The University of Tokyo
• Principal Investigator: 阿久根 徹 東京大学, 医学部附属病院, 特任准教授 (60282662)
• Co-Investigator(Kenkyū-buntansha): 吉村 典子 東京大学, 医学部附属病院, 特任准教授 (60240355) ; 村木 重之 東京大学, 医学部附属病院, 特任助教 (40401070) ; 岡 敬之 東京大学, 医学部附属病院, 特任助教 (60401064)
• Keywords: MRI / 脊椎疾患 / コホート

Research Abstract

研究初年度である今年度は、一般地域住民集団において車両搭載型MRI撮像装置用いて実施した全脊椎MRI画像と、検診時に収集した400項目以上の詳細な臨床情報のデータベース化作業を進めるとともに、蓄積されたデータベース情報の中から頚部脊柱管狭窄と腰部脊柱管狭窄のデータを用いて検討を行い、一般住民における有病率の解明を行った。MRI検診への参加を表明した1,011名(男性335名、女性676名、平均年齢66.3歳)のうち、ペースメーカー装着その他不適応者や体動による画像読影困難者を除外して、MRI画像を解析できた977名の頚椎および985名の腰椎画像所見と臨床情報を解析した結果、対象集団の頚髄圧迫の頻度は全体で24.4%であり、男女別では男性29.4%、女性22.4%で有意に男性に多く、男女ともに50歳代以降に経年的に頚髄圧迫の頻度が高かった。これを本邦の年齢別人口構成にあてはめて計算すると、日本における頚髄圧迫者数(40歳以上)は1470万人(男性780万人、女性690万人)にのぼることが明らかとなった。また、対象集団における腰部脊柱管狭窄症の有病率は9.3%(男性10.1%、女性8.9%)で、男女ともに50歳代以降に有病率が高値を示す傾向となり、同様に本邦の年齢別人口構成にあてはめて計算すると、日本における推定有病者数(40歳以上)は580万人(男性300万人、女性280万人)にのぼることが明らかとなった。一方、MRI画像評価システムでは自動計測のためのアルゴリズムを開発中であり、また脊椎疾患の疾患感受性遺伝子探索研究ではゲノムワイド関連解析と高密度ジェノタイピング法を用いて候補領域の絞り込み作業を進めている。本研究初年度に、日本人一般住民集団における中高年者の頚部脊柱管狭窄(頚髄圧迫)および腰部脊柱管狭窄症の有病率と推定有病者数を解明できた意義は大きいと考えられる。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

全脊椎MRI画像データと臨床情報のデータベース化、そのデータを用いた脊椎疾患の疫学指標の解明、さらにMRI画像評価システムの開発と脊椎疾患感受性遺伝子探索研究が進行中であり、おおむね計画に沿って進行中である。特に研究初年度である今年度は、従来レントゲン検診では成し得なかった頚部脊柱管狭窄(頚髄圧迫)と、腰部脊柱管狭窄症の一般住民集団における有病率を解明することができ、それらの日本人推定有病者数を解明することができた。これらは、今後の脊椎疾患の予防対策を進める上で基盤となる重要な疫学指標であり意義は大きい。

Strategy for Future Research Activity

本研究課題の計画変更はなく、次年度以降、当初の計画に従い、研究を進めていく。

Research Products

• [Journal Article] Health-related quality of life in subjects with low back pain and knee pain in a population-based cohort study of Japanese men : the ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Enyo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Spine (Phila Pa 1976) Volume: 36 Pages: 1312-1319
• [Journal Article] Biochemical markers of bone turnover as predictors for occurrence of osteoporosis and osteoporotic fractures in men and women : Ten-year follow-up of the Taiji cohort study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Mod Rheumatol Volume: 21 Pages: 608-620
• [Journal Article] Prevalence of falls and its association with knee osteoarthritis and lumbar spondylosis as well as knee and lower back pain in Japanese men and women (2011)
  • Author(s): Muraki S, Akune T, Oka H, En-Yo Y, Yoshida M, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arthritis Care Res (Hoboken) Volume: 63 Pages: 1425-1431
• [Journal Article] Capacity of endogenous sex steroids to predict bone loss in Japanese men : 10-year follow-up of the Taiji Cohort Study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: J Bone Miner Metab Volume: 29 Pages: 96-102
  • Peer Reviewed
• [Journal Article] Association of knee osteoarthritis with the accumulation of metabolic risk factors such as overweight, hypertension, dyslipidemia, and impaired glucose tolerance in Japanese men and women : the ROAD study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: J Rheumatol Volume: 38 Pages: 921-930
  • Peer Reviewed
• [Journal Article] Association of occupational activity with joint space narrowing and osteophytosis in the medial compartment of the knee : the ROAD study (2011)
  • Author(s): Muraki S, Oka H, Akune T, Enyo Y, Yoshida M, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 19 Pages: 840-846
  • Peer Reviewed
• [Journal Article] Changes in serum levels of biochemical markers of bone turnover over 10 years among Japanese men and women : associated factors and birth-cohort effect ; the Taiji study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: J Bone Miner Metab Volume: 29 Pages: 699-708
  • Peer Reviewed
• [Journal Article] Reference values for hand grip strength, muscle mass, walking time, and one-leg standing time as indices for locomotive syndrome and associated disability : The second survey of the ROAD study (2011)
  • Author(s): Yoshimura N, Oka H, Muraki S, Akune T, Hirabayashi N, Matsuda S, Nojiri T, Hatanaka K, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Kawaguchi H, Nakamura K
  • Journal Title: J Orthop Sci Volume: 16 Pages: 768-777
  • Peer Reviewed
• [Journal Article] Association of vitamin D status with knee pain and radiographic knee osteoarthritis (2011)
  • Author(s): Muraki S, Dennison E, Jameson K, Boucher BJ, Akune T, Yoshimura N, Judge A, Arden NK, Javaid K, Cooper C
  • Journal Title: Osteoarthritis Cartilage Volume: 19 Pages: 1301-1306
  • Peer Reviewed
• [Journal Article] Independent association of joint space narrowing and osteophyte formation at the knee with health-related quality of life in Japan : A cross-sectional study (2011)
  • Author(s): Muraki S, Oka H, Akune T, EnYo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arthritis Rheum Volume: 63 Pages: 3859-3864
  • Peer Reviewed
• [Presentation] Incidence and risk factors for radiographic lumbar spondylosis : the ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: Osteoarthritis Research Society International (OARSI) 2011 World Congress on Osteoarthritis
  • Place of Presentation: San Diego, USA
  • Year and Date: 20110916-20110920
• [Presentation] Vitamin D Insufficiency and Occurrence of Osteoporosis and Disability : the ROAD study (2011)
  • Author(s): Yoshimura N, Muraki M, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: The 33rd Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: San Diego, USA
  • Year and Date: 20110916-20110920
• [Presentation] Incidence of multiple falls and risk factors in a longitudinal population based cohort study in Japan : the ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: The 33rd Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: San Diego, USA
  • Year and Date: 20110916-20110920
• [Presentation] Risk factors for the incidence and progress rate of radiographic knee osteoarthritis in Japanese men and women : the ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: Osteoarthritis Research Society International (OARSI) 2011 World Congress on Osteoarthritis
  • Place of Presentation: California, USA
  • Year and Date: 20110915-20110918
• [Presentation] Vitamin D insufficiency and deficiency as a risk factor for fast bone loss among elderly men and women : The ROAD study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: The 2nd Asia-Pacific Osteoporosis and Bone Meeting
  • Place of Presentation: Gold Coast, Australia
  • Year and Date: 20110904-20110908
• [Presentation] Risk factors for multiple falls in a longitudinal population-based cohort study in Japan : the ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Nakamura K, Kawaguchi H, Yoshimura N
  • Organizer: The 2nd Asia-Pacific Osteoporosis and Bone Meeting
  • Place of Presentation: Gold Coast, Australia
  • Year and Date: 20110904-20110908
• [Presentation] Role of neuromuscular function in predicting the occurrence of disability : The ROAD study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Organizer: IEA World Congress of Epidemiology
  • Place of Presentation: Edinburgh, Scotland
  • Year and Date: 20110807-20110811
• [Presentation] The Prevalence of the lumbar spinal stenosis with Mobile MRI in a population-based cohort : The Road-MRI Study (2011)
  • Author(s): Ishimoto Y, Yoshida M, Yamada H, Nagata K, Hashizume H, Takiguchi N, Shigeyuki M, Oka H, Akune T, Yoshimura N
  • Organizer: Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS)
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 20110614-20110618
• [Presentation] Prevalence of cervical cord compression and its relations to physical signs and performances in a Japanese population-based cohort : The ROAD-MRI Study (2011)
  • Author(s): Nagata K, Yoshida M, Hashizume H, Yamada H, Ishimoto Y, Takiguchi N, Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: The 8th Combined Congress of the Spine and Pediatric Sections, Asia Pacific Orthopaetic Association (APOA)
  • Place of Presentation: Gifu, Japan
  • Year and Date: 20110601-04
• [Presentation] The prevalence of lumbar spinal stenosis using MRI in a local cohort : The ROAD-MRI Study (2011)
  • Author(s): Ishimoto Y, Yamada H, Hashizume H, Nagata K, Takiguchi N, Yoshida M, Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: The 8th Combined Congress of the Spine and Pediatric Sections, Asia Pacific Orthopaetic Association (APOA)
  • Place of Presentation: Gifu, Japan
  • Year and Date: 20110601-04
• [Presentation] 地域住民における頚椎MRI画像所見の検討-The ROAD-MRI Study (2011)
  • Author(s): 長田圭司、吉田宗人、橋爪洋、石元優々、山田宏、瀧口登、村木重之、岡敬之、阿久根徹、吉村典子
  • Organizer: 第84回日本整形外科学会
  • Place of Presentation: 横浜
  • Year and Date: 20110512-20110515
• [Presentation] 地域住民における腰部脊柱管狭窄症の有病率-The ROAD-MRI Study (2011)
  • Author(s): 石元優々, 吉田宗人, 山田宏, 長田圭司, 橋爪洋, 瀧口登, 村木重之, 岡敬之, 阿久根徹, 吉村典子
  • Organizer: 第84回日本整形外科学会
  • Place of Presentation: 横浜
  • Year and Date: 20110512-15