A population-based cohort study of spinal diseases using MRI

2013 Fiscal Year Final Research Report

• Project/Area Number: 23390357
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: AKUNE Toru 東京大学, 医学部附属病院, 准教授 (60282662)
• Co-Investigator(Kenkyū-buntansha): MURAKI Shigeyuki 東京大学, 医学部附属病院, 特任助教 (40401070) ; OKA Hiroyuki 東京大学, 医学部附属病院, 特任助教 (60401064) ; YOSHIMURA Noriko 東京大学, 医学部附属病院, 特任准教授 (60240355)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 脊椎疾患 / 疫学 / MRI / コホート研究

Research Abstract

This study was investigated to elucidate epidemiologic evidence of spinal diseases using MRI in population-based cohorts of Japanese men and women. 1,011 participants (335 men and 676 women, mean 66.3 years) were enrolled. Participants completed an interviewer-administered questionnaire and underwent anthropometric measurements and assessments of physical performance. Radiograph and MRI of cervical, thoracic and lumbar spine were examined. Among 1,011 participants, those who had MRI-sensitive implanted devices and other disqualifiers were excluded. Prevalence of cervical spinal cord compression on MRI was 24.4% and that of lumbar spinal stenosis was 9.3% in the study population. Based on these data, 14.7 million were estimated to have cervical spinal cord compression and 5.8 million were estimated to have lumbar spinal stenosis in Japan.

Research Products

• [Journal Article] Exercise habits during middle age are associated with lower prevalence of sarcopenia : the ROAD study (2014)
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Osteoporos Int Volume: 25 Pages: 1081-8
• [Journal Article] Prevalence and progression of radiographic ossification of the posterior longitudinal ligament and associated factors in the Japanese population : a 3-year follow-up of the ROAD study (2014)
  • Author(s): Yoshimura N, Nagata K, Muraki S, Oka H, Yoshida M, Enyo Y, Kagotani R, Hashizume H, Yamada H, Ishimoto Y, Teraguchi M, Tanaka S, Kawaguchi H, Toyama Y, Nakamura K, Akune T
  • Journal Title: Osteoporos Int Volume: 25 Pages: 1089-98
• [Journal Article] Prevalence and distribution of intervertebral disc degeneration over the entire spine in a population-based cohort : the Wakayama Spine Study (2014)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Minamide A, Oka H, Ishimoto Y, Nagata K, Kagotani R, Takiguchi N, Akune T, Kawaguchi H, Nakamura K, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 22 Pages: 104-10
• [Journal Article] Associations between radiographic lumbar spinal stenosis and clinical symptoms in the general population : the Wakayama Spine Study (2013)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 21 Pages: 783-8
• [Journal Article] Incidence and risk factors for radiographic lumbar spondylosis and lower back pain in Japanese men and women : the ROAD study (2012)
  • Author(s): Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 20 Pages: 712-718
• [Journal Article] Prevalence of vertebral fracture in Asian men and women : Comparison between Hong Kong, Thailand, Indonesia and Japan (2012)
  • Author(s): Kwok AW, Leung JC, Chan AY, Au BS, Lau EM, Yurianto H, Yuktanandana P, Yoshimura N, Muraki S, Oka H, Akune T, Leung PC
  • Journal Title: Public Health Volume: 126 Pages: 523-531
• [Journal Article] Prevalence of symptomatic lumbar spinal stenosis and its association with physical performance in a population-based cohort in Japan : the Wakayama Spine Study (2012)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: 20 Pages: 1103-1108
• [Journal Article] Prevalence of cervical cord compression and its association with physical performance in a population-based cohort in Japan : the Wakayama spine study (2012)
  • Author(s): Nagata K, Yoshimura N, Muraki S, Hashizume H, Ishimoto Y, Yamada H, Takiguchi N, Nakagawa Y, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Spine (Phila Pa 1976) Volume: 37 Pages: 1892-1898
• [Journal Article] Health-related quality of life in subjects with low back pain and knee pain in a population-based cohort study of Japanese men : the ROAD study (2011)
  • Author(s): Muraki S, Akune T, Oka H, Enyo Y, Yoshida M, Saika A, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Spine (Phila Pa 1976) Volume: 36 Pages: 1312-1319
• [Journal Article] Biochemical markers of bone turnover as predictors for occurrence of osteoporosis and osteoporotic fractures in men and women : Ten-year follow-up of the Taiji cohort study (2011)
  • Author(s): Yoshimura N, Muraki S, Oka H, Kawaguchi H, Nakamura K, Akune T
  • Journal Title: Mod Rheumatol Volume: 21 Pages: 608-620
• [Journal Article] Prevalence of falls and its association with knee osteoarthritis and lumbar spondylosis as well as knee and lower back pain in Japanese men and women (2011)
  • Author(s): Muraki S, Akune T, Oka H, En-Yo Y, Yoshida M, Nakamura K, Kawaguchi H, Yoshimura N
  • Journal Title: Arthritis Care Res (Hoboken) Volume: 63 Pages: 1425-1431
• [Journal Article] Incidence of certified need of care in the long-term care insurance system and its risk factors in the elderly of Japanese population-based cohorts
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N
  • Journal Title: The ROAD study. Geriatr Gerontol Int Volume: (in press)
• [Journal Article] Association of physical activities of daily living with the incidence of certified need of care in the long-term care insurance system of Japan : the ROAD study
  • Author(s): Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Tokimura F, Yoshida H, Suzuki T, Nakamura K, Yoshimura N
  • Journal Title: J Orthop Sci Volume: (in press)
• [Journal Article] Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) of the whole spine and its association with lumbar spondylosis and knee osteoarthritis : the ROAD study
  • Author(s): Kagotani R, Yoshida M, Muraki S, Oka H, Hashizume H, Yamada H, Enyo Y, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N
  • Journal Title: J Bone Miner Metab Volume: (in press)
• [Journal Article] Prevalence, incidence, and progression of lumbar spondylosis by gender and age strata
  • Author(s): Muraki S, Yoshimura N, Akune T, Tanaka S, Takahashi I, Fujiwara S
  • Journal Title: Mod Rheumatol Volume: (in press)
• [Journal Article] Prevalence of knee pain, lumbar pain and its co-existence in Japanese men and women : The LOCOMO (Longitudinal Cohorts of Motor System Organ) study
  • Author(s): Yoshimura N, Akune T, Fujiwara S, Shimizu Y, Yoshida H, Omori G, Sudo A, Nishiwaki Y, Yoshida M, Shimokata H, Suzuki T, Muraki S, Oka H, Nakamura K
  • Journal Title: J Bone Miner Metab Volume: (in press)
• [Presentation] 定量評価ソフトウェアにて求めたX線画像, MRI計測値と体格との関連 : The ROAD Study (2013)
  • Author(s): 岡敬之, 川口浩, 阿久根徹, 村木重之, 田中栄, 吉村典子
  • Organizer: 第86回日本整形外科学会学術総会
  • Place of Presentation: 広島市
  • Year and Date: 20130523-26
• [Presentation] 大規模住民コホートにおける頸髄圧迫, 腰部脊柱管狭窄症と歩行機能, 体幹バランスとの関係 (2013)
  • Author(s): 長田圭司, 橋爪洋, 石元優々, 山田宏, 南出晃人, 中川幸洋, 村木重之, 岡敬之, 阿久根徹, 吉村典子, 吉田宗人
  • Organizer: 第86回日本整形外科学会学術総会
  • Place of Presentation: 広島市
  • Year and Date: 20130523-26
• [Presentation] 頸椎MRIを用いた大規模住民コホートにおける頸髄症の関連因子 (2013)
  • Author(s): 長田圭司, 橋爪洋, 石元優々, 山田宏, 南出晃人, 中川幸洋, 村木重之, 岡敬之, 阿久根徹, 吉村典子, 吉田宗人
  • Organizer: 第86回日本整形外科学会学術総会
  • Place of Presentation: 広島市
  • Year and Date: 20130523-26
• [Presentation] 腰部脊柱管狭窄症と骨粗鬆症の合併は腰痛, QOL と関連するか-一般住民コホートを用いた横断的研究 (2013)
  • Author(s): 橋爪洋, 吉村典子, 石元優々, 山田宏, 長田圭司, 岡敬之, 村木重之, 阿久根徹, 瀧口登, 吉田宗人
  • Organizer: 第86回日本整形外科学会学術総会
  • Place of Presentation: 広島市
  • Year and Date: 20130523-26
• [Presentation] 大規模住民コホートにおける頸髄圧迫, 腰部脊柱管狭窄症と歩行機能, 体幹バランスとの関係 (2013)
  • Author(s): 長田圭司, 吉村典子, 橋爪洋, 石元優々, 山田宏, 瀧口登, 南出晃人, 中川幸洋, 村木重之, 岡敬之, 阿久根徹, 吉田宗人
  • Organizer: 第42回日本脊椎脊髄病学会
  • Place of Presentation: 宜野湾市
  • Year and Date: 20130425-27
• [Presentation] 全脊柱MRIを用いた大規模住民コホートにおける頸髄圧迫と腰部脊柱管狭窄の合併頻度 (2013)
  • Author(s): 長田圭司, 吉村典子, 橋爪洋, 石元優々, 山田宏, 瀧口登, 南出晃人, 中川幸洋, 村木重之, 岡敬之, 阿久根徹, 吉田宗人
  • Organizer: 第42回日本脊椎脊髄病学会
  • Place of Presentation: 宜野湾市
  • Year and Date: 20130425-27
• [Presentation] 大規模住民コホートにおける腰部脊柱管狭窄症と骨粗鬆症の実態調査 (2013)
  • Author(s): 橋爪洋, 吉村典子, 石元優々, 長田圭司, 阿久根徹, 岡敬之, 村木重之, 瀧口登, 山田宏, 吉田宗人
  • Organizer: 第42回日本脊椎脊髄病学会
  • Place of Presentation: 宜野湾市
  • Year and Date: 20130425-27
• [Presentation] 頸椎後縦靭帯骨化症の有病率とその特徴 : The ROAD Study (2013)
  • Author(s): 吉村典子, 長田圭司, 延與良夫, 吉田宗人, 村木重之, 岡敬之, 田中栄, 川口浩, 中村耕三, 阿久根徹
  • Organizer: 第42回日本脊椎脊髄病学会
  • Place of Presentation: 宜野湾市
  • Year and Date: 20130425-27
• [Presentation] Association of diffuse idiopathic skeletal hyperostosis and bone mineral density and marker of bone metabolism : the ROAD study (2013)
  • Author(s): Kagotani R, Muraki S, Oka H, Yoshida M, Hashizume H, Yamada H, Nagata K, Ishimoto Y, Teraguchi M, Tanaka S, Nakamura K, Kawaguchi H, Akune T, Yoshimura N
  • Organizer: IOF-ESCEO European Congress on Osteoporosis and Osteoarthritis
  • Place of Presentation: Rome, Italy
  • Year and Date: 20130417-20
• [Presentation] 定量評価ソフトウエアにて求めたX 線画像, MRI 計測値と体格との関連 : The ROAD Study (2012)
  • Author(s): 岡敬之, 村木重之, 阿久根徹, 中村耕三, 川口浩, 吉村典子
  • Organizer: 第85回日本整形外科学会
  • Place of Presentation: 京都
  • Year and Date: 20120517-20
• [Presentation] 大規模一般住民コホートにおける脊柱管前後径の検討 (2012)
  • Author(s): 長田圭司, 吉田宗人, 橋爪洋, 石元優々, 山田宏, 瀧口登, 村木重之, 岡敬之, 阿久根徹, 吉村典子
  • Organizer: 第85回日本整形外科学会
  • Place of Presentation: 京都
  • Year and Date: 20120517-20
• [Presentation] 腰部脊柱管狭窄症の最新知見 腰部脊柱管狭窄症の疫学The Wakayama Spine Study (2012)
  • Author(s): 山田宏, 石元優々, 長田圭司, 瀧口登, 橋爪洋, 村木重之, 岡敬之, 阿久根徹, 吉村典子, 吉田宗人
  • Organizer: 第85回日本整形外科学会
  • Place of Presentation: 京都
  • Year and Date: 20120517-20
• [Presentation] The ROAD project : Genetics of OA in the ROAD study (2012)
  • Author(s): Akune T
  • Organizer: Osteoarthritis Research Society International (OARSI) 2012 World Congress on Osteoarthritis
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20120426-29
• [Presentation] 頸椎脊柱管前後径の年代別評価 大規模一般住民コホートを用いた頸椎単純X 線の検討 (2012)
  • Author(s): 長田圭司, 橋爪洋, 石元優々, 山田宏, 南出晃人, 中川幸洋, 河合将紀, 岩崎博, 木岡雅彦, 瀧口登, 村木重之, 岡敬之, 阿久根徹, 吉村典子, 吉田宗人
  • Organizer: 第41回日本脊椎脊髄病学会
  • Place of Presentation: 久留米
  • Year and Date: 20120419-21
• [Presentation] 頸椎画像所見と頸髄圧迫との関連 大規模住民コホートを用いた検討 (2012)
  • Author(s): 長田圭司, 橋爪洋, 石元優々, 山田宏, 南出晃人, 中川幸洋, 河合将紀, 岩崎博, 木岡雅彦, 瀧口登, 村木重之, 岡敬之, 阿久根徹, 吉村典子, 吉田宗人
  • Organizer: 第41回日本脊椎脊髄病学会
  • Place of Presentation: 久留米
  • Year and Date: 20120419-21
• [Presentation] 一般住民における腰部脊柱管狭窄症とその身体運動機能に及ぼす影響 the Wakayama Spine Study (2012)
  • Author(s): 石元優々, 吉田宗人, 長田圭司, 山田宏, 橋爪洋, 瀧口登, 村木重之, 岡敬之, 阿久根徹, 吉村典子
  • Organizer: 第41回日本脊椎脊髄病学会
  • Place of Presentation: 久留米
  • Year and Date: 20120419-21
• [Presentation] The prevalence of lumbar spinal stenosis using mobile MRI in local inhabitants : The ROAD-MRI study (2012)
  • Author(s): Ishimoto Y, Yamada H, Nagata K, Hashizume H, Takiguchi N, Yoshida M. Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: 2012 Annual Meeting of American Academy of Orthopaedic Surgeons (AAOS)
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20120207-11
• [Presentation] The Prevalence Of Cervical Cord Compression Using Mobile MRI In Local Inhabitants : The Road-MRI Study (2012)
  • Author(s): Nagata K, Hashizume H, Ishimoto Y, Yamada H, Takiguchi N, Yoshida M. Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: 2012 Annual Meeting of American Academy of Orthopaedic Surgeons (AAOS)
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20120207-11
• [Presentation] The Prevalence of the lumbar spinal stenosis with Mobile MRI in a population-based cohort : The ROAD-MRI Study (2011)
  • Author(s): Ishimoto Y, Yoshida M, Yamada H, Nagata K, Hashizume H, Takiguchi N, Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: Annual Meeting of the International Society for the Study of the Lumbar Spine (ISSLS)
  • Place of Presentation: Gothenburg, Sweden
  • Year and Date: 20110614-18
• [Presentation] Prevalence of cervical cord compression and its relations to physical signs and performances in a Japanese population-based cohort : The ROAD-MRI Study (2011)
  • Author(s): Nagata K, Yoshida M, Hashizume H, Yamada H, Ishimoto Y, Takiguchi N, Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: The 8th Combined Congress of the Spine and Pediatric Sections, Asia Pacific Orthopaetic Association (APOA)
  • Place of Presentation: Gifu, Japan
  • Year and Date: 20110601-04
• [Presentation] The prevalence of lumbar spinal stenosis using MRI in a local cohort : The ROAD-MRI Study (2011)
  • Author(s): Ishimoto Y, Yamada H, Hashizume H, Nagata K, Takiguchi N, Yoshida M, Muraki S, Oka H, Akune T, Yoshimura N
  • Organizer: The 8th Combined Congress of the Spine and Pediatric Sections, Asia Pacific Orthopaetic Association (APOA)
  • Place of Presentation: Gifu, Japan
  • Year and Date: 20110601-04
• [Presentation] 地域住民における腰部脊柱管狭窄症の有病率-The ROAD-MRI Study (2011)
  • Author(s): 石元優々, 吉田宗人, 山田宏, 長田圭司, 橋爪洋, 瀧口登, 村木重之, 岡敬之, 阿久根徹, 吉村典子
  • Organizer: 第84回日本整形外科学会
  • Place of Presentation: 横浜
  • Year and Date: 20110512-15
• [Presentation] 地域住民における頚椎MRI 画像所見の検討-The ROAD-MRI Study (2011)
  • Author(s): 長田圭司, 吉田宗人, 橋爪洋, 石元優々, 山田宏, 瀧口登, 村木重之, 岡敬之, 阿久根徹, 吉村典子
  • Organizer: 第84回日本整形外科学会
  • Place of Presentation: 横浜
  • Year and Date: 20110512-15