Therapeutic potential of vascular stem cells for ACL reconstruction surgery

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390365
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kobe University
• Principal Investigator: KUROSAKA MASAHIRO 神戸大学, 医学(系)研究科(研究院), 教授 (70170115)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Tomoyuki 神戸大学, 医学部付属病院, 助教 (50546588) ; MATSUSHITA Takehiko 神戸大学, 医学部付属病院, 助教 (40467650) ; KURODA Ryosuke 神戸大学, 医学(系)研究科(研究院), 准教授 (80379362)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 膝前十字靱帯 / 再生医療 / 組織移植

Outline of Final Research Achievements

The purpose of the study was to perform "Anterior cruciate ligament (ACL) reconstruction with autologous ruptured tissue for patients with ACL injury." and assess the safety and efficacy. Prior to the clinical trial, we confirmed the efficacy of CD34+ cell or ruptured tissue transplantation for ACL reconstruction in rat and canine ACL reconstruction model. These series exhibited the reduction of tunnel enlargement by the treatment. So, we performed pilot study in which 5 patients were enrolled for tissue transplantation group and 5 patients for conventional ACL reconstruction group. The results showed the reduction of tunnel enlargement in the tissue group despite of no significant difference in clinical scores. So, we have to seek for the factors influencing on the efficacy of this treatment in future.

Free Research Field

整形外科学