2013 Fiscal Year Final Research Report
Investigation of the mechanisms of personalized-cancer vaccination by REIC/Dkk-3 based gene therapy.
Project/Area Number |
23390382
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
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Research Institution | Okayama University |
Principal Investigator |
KUMON Hiromi 岡山大学, 医歯(薬)学総合研究科, 教授 (30144760)
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Co-Investigator(Kenkyū-buntansha) |
HUH Namho 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70142023)
WATANABE Masami 岡山大学, 岡山大学病院, 准教授 (70444677)
SAKAGUCHI Masakiyo 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70379840)
KAKU Haruki 岡山大学, 岡山大学病院, 講師 (60346426)
UEKI Hideo 岡山大学, 医学部, 技術専門職員 (90537218)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Keywords | 遺伝子治療 / 癌ワクチン / 骨髄系免疫抑制細胞 / REIC/Dkk3 |
Research Abstract |
In situ gene therapy with tumor suppressor, REIC/Dkk-3, induces cancer-specific apoptosis and activation of anti-cancer immune. The combined effects seem to be important for the therapeutic outcomes of personalized-cancer vaccination. In this study, we elucidated that the suppressive effect of REIC/Dkk-3 on the differentiation of MDSC and the following CTL activation are important for the mechanism of the personalized-cancer vaccination.
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Research Products
(23 results)
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[Journal Article] A novel gene expression system strongly enhances the anticancer effects of a REIC/Dkk-3-encoding adenoviral vector2014
Author(s)
Watanabe M., Sakaguchi M., Kinoshita R., Kaku H., Ariyoshi Y., Ueki H., Tanimoto R., Ebara S., Ochiai K., Futami J., Li SA., Huang P., Nasu Y., Huh NH., Kumon H
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Journal Title
Oncology Reports
Volume: 31巻
Pages: 1089-95
DOI
Peer Reviewed
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[Journal Article] Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-12011
Author(s)
Ochiai K., Watanabe M., Ueki H., Huang P., Fujii Y., Nasu Y., Noguchi H., Hirata T., Sakaguchi M., Huh NH., Kashiwakura Y., Kaku H., Kumon H
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Journal Title
Biochem Biophys Res Commun
Volume: 412巻
Pages: 391-395
DOI
Peer Reviewed
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