2013 Fiscal Year Final Research Report
Prevent and therapeutic strategy bycombination of microarray and proteomics for seasonal allergic rhinitis caused by Japanese cedar pollen.
| Project/Area Number |
23390397
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Emiko 筑波大学, 医学(系)研究科(研究院), 准教授 (40344882)
SHAKASHITA Masafumi 福井大学, 医学部附属病院, 助教 (40555455)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | スギ花粉症 / アレルギー性鼻炎 / 網羅的解析 / 遺伝子多型 / ORMDL-3 / Intelectin-1 / Apolipoprotein A4 / C3a |
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| Research Abstract |
Sixty percent of adult in Japan have Japanese cedar pollen (JCP)-specific IgE. Prevalence of allergic rhinitis (AR) caused by JCP (AR-JCP) in Japanese adults is 40%. In this study we investigated AR-JCP-related gene by genome wide associated study, and gene expression by microarray and proteome analysis. We found that ORMDL-3, CST-1, IL-33, Allergin-1, and Apolipoprotein A4 are associated with onset of AR-JCP. Several SNP are also found to be associated with AR-JCP.
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