2013 Fiscal Year Final Research Report
Lymph node targeting by human interferon-ß with hyaluronic acid based on metal coordination
| Project/Area Number |
23390406
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
AKIRA Saito 北海道大学, 医学(系)研究科(研究院), 客員研究員 (70507574)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yuhei 北海道大学, 大学院・医学研究科, 教授 (70271674)
FURUKAWA Hiroshi 北海道大学, 大学院・医学研究科, 講師 (00399924)
OYAMA Akihiko 北海道大学, 北海道大学病院, 講師 (70374486)
FUNAYAMA Emi 北海道大学, 大学院・医学研究科, 助教 (10533630)
HAYASHI Toshihiko 北海道大学, 大学院・歯学研究科, 准教授 (00432146)
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| Co-Investigator(Renkei-kenkyūsha) |
TABATA Yasuhiko 京都大学, 再生医科学研究所, 教授 (50211371)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | メラノーマ / インターフェロンβ / ヒアルロン酸 / ドラッグデリバリー / リンパ節転移 |
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| Research Abstract |
The purpose of this study was to reduce the side effects and the pain caused by frequent injections of IFN-beta for melanoma while specifically targeting the lymph nodes by taking advantage of metal coordination to bind IFN-beta to hyaluronic acid. Sustained release of IFN-beta by conjugation with HA prolongs lymphatic retention. IFN-beta-hyaluronic acid conjugates can be given as an adjuvant therapy post-surgery to reduce the risk of recurrence and eradicate melanoma residuals, such as micrometastases. In addition, due to the sustained release characteristics of the conjugate, weekly injections for melanoma could replace conventional daily injections, thereby reducing pain as well as healthcare costs.
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