2013 Fiscal Year Final Research Report
Analysis of oral cancer oncogenic mechanism mediate by the export and stabilization of ARE-mRNA
| Project/Area Number |
23390416
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHINDOH Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
TOTSUKA Yasunori 北海道大学, 名誉教授 (00109456)
KITAMURA Tetsuya 北海道大学, 大学院・歯学研究科, 助教 (00451451)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 口腔がん / HuR / pp32 / pp32r1 / Transportin2 / ARE-mRNA / 結合タンパク |
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| Research Abstract |
In this study, we examined the role of HuR binding protein, Transportin 2 (TNPO2), pp32, pp32r1 in order to understand the oncogenic mechanism mediated by the export and stabilization of ARE-mRNA. TNPO2 had some relation with the stabilization of ARE-mRNA. pp32 inhibited the export and stabilization of ARE-mRNA, furthermore, pp32r1 suppressed the degradation of HuR in the cytoplasm of cells.
These results indicate that TNPO2, pp32, pp32r1 are the regulators of the ARE-mRNA stabilization and a new cancer therapy by controlling these proteins is promising.
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