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2013 Fiscal Year Final Research Report

Roles of new ion channel involved in the regeneration/development of the periodontal Ruffini endings

Research Project

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Project/Area Number 23390418
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionNiigata University

Principal Investigator

MAEDA Takeyasu  新潟大学, 医歯学系, 教授 (40183941)

Co-Investigator(Kenkyū-buntansha) IZUMI Kenji  新潟大学, 医歯学系, 教授 (80242436)
INOUE Kayoko (NOZAWA Kayoko)  新潟大学, 医歯学系, 特任准教授 (90303130)
KAWANO Yoshiro  新潟大学, 医歯学系, 助教 (60303129)
Research Collaborator OHZAMA Atsushi  新潟大学, 医歯学系, 准教授 (40266169)
SUZUKI Akiko  新潟大学, 医歯学系, 特任助教
HARADA Fumiko  新潟大学, 医歯学系, 科研費雇用研究員
YOSHII Tomoko  新潟大学, 大学院・医歯学総合研究科, 大学院生(現研究員)
IHYO Chika  新潟大学, 大学院・医歯学総合研究科, 大学院生(現教務補佐員)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords歯根膜 / 機械受容器 / ルフィニ神経終末 / ASIC3 / イオンチャネル / 再生
Research Abstract

This study examined the regeneration process of the periodontal Ruffini ending, an essential mecahnoreceptor, based on the changes in the expression pattern of acid-sensing ion channel-3 (ASIC3) at the periodontal ligament and trigeminal ganglion. The findings obtained from the nerve injury model (resection of the inferior alveoar nerve at one side) indicate that this molecule is not direcly involved in the axonal regeneration of the periodontal Ruffini endings but rather in neuron-glial interactions such as control of neuronal activity in the trigeminal ganglion.

  • Research Products

    (14 results)

All 2015 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) (of which Invited: 1 results) Book (4 results)

  • [Journal Article] Immunoexpression of aquaporin-1 in the rat periodontal ligament during experimental tooth movement2012

    • Author(s)
      T. Yoshii, F. Harada, I Saito, K. Nozawa-Inoue, Y. Kawano, T. Maeda
    • Journal Title

      Biomedical Research

      Volume: 33(4) Pages: 225-233

    • URL

      https://www.jstage.jst.go.jp/article/biomedres/33/4/33_225/_article

    • Peer Reviewed
  • [Journal Article] e injury provides an essential delivery tool for neuropathic pain attenuation2012

    • Author(s)
      H.M. Zakir, R.M. Mostafeezur, A. Suzuki, S. Hitomi, T. Maeda, K. Seo, Y. Yamada, K. Yamamura, S. Lev, A.M. Binshtok, K. Iwata, J. Kitagawa
    • Journal Title

      PLoS One

      Volume: 7(9) Pages: e44023

    • DOI

      10.1371/journal.pone.0044023

    • Peer Reviewed
  • [Presentation] Contribution of BDNF to nerve regeneration and neuroma formation after nerve injury2013

    • Author(s)
      K. Seo, H. Yoshikawa, Y.M. Valverde Guevara, T. Maeda, M. Kurose, K. Yamamura
    • Organizer
      8th Congress of the European Federation of IASP
    • Place of Presentation
      Florence, Italy
    • Year and Date
      20131009-12
  • [Presentation] Ruffini ending as a primary mechanoreceptor in periodontal ligament ; Its morphology, histochemical features and neuroplasticity-2013

    • Author(s)
      T. Maeda
    • Organizer
      KPPIKG 2013
    • Place of Presentation
      KPPIKG 2013(
    • Year and Date
      20130228-0302
    • Invited
  • [Presentation] ラット切歯歯根膜ルフィニ神経終末の再生過程におけるASIC3 の役割2013

    • Author(s)
      井表千馨, 原田史子, 斎藤功, 前田健康
    • Organizer
      平成25年度新潟歯学会第2回例会
    • Place of Presentation
      新潟
    • Year and Date
      2013-11-19
  • [Presentation] Possible role of BDNF on nerve regeneration following transection of inferior alveolar nerve2013

    • Author(s)
      Y.M. Valverde Guevara, H. Yoshikawa, I. Saito, T. Maeda, K. Seo
    • Organizer
      平成25年度新潟歯学会総会
    • Place of Presentation
      新潟
    • Year and Date
      2013-04-20
  • [Presentation] Effects of antibody to BDNF on nerve regeneration following transection of inferior alveolar nerve2012

    • Author(s)
      Y.M. Valverde Guevara, H. Yoshikawa, K. Seo, T. Maeda, I. Saito
    • Organizer
      42nd Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      20121013-17
  • [Presentation] 実験的歯の移動時におけるラット臼歯歯根膜のアクアポリン-1免疫発現2012

    • Author(s)
      吉居朋子, 斎藤功, 前田健康, 原田史子, 河野芳朗
    • Organizer
      第71回日本矯正歯科学会
    • Place of Presentation
      盛岡
    • Year and Date
      20120926-28
  • [Presentation] Dental Innervation2011

    • Author(s)
      T. Maeda
    • Organizer
      Congreso Magno De Egresados De Vuelta A Casa
    • Place of Presentation
      Torreon, Mexico
    • Year and Date
      2011-09-16
  • [Presentation] Mechanoreceptive Ruffini endings innervating by ASIC3- positive trigeminal ganglion neurons2011

    • Author(s)
      T. Maeda, et al
    • Organizer
      8th International Brain Research Organization World Congress of Neuroscience
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2011-07-17
  • [Book] 第6章 歯周組織の神経支配(口腔組織発生学第2版)2015

    • Author(s)
      前田健康
    • Publisher
      医歯薬出版(印刷中)
  • [Book] 口腔の構造と機能(口腔科学)2013

    • Author(s)
      前田健康
    • Total Pages
      8-22
    • Publisher
      朝倉書店
  • [Book] 歯の構造と機能(口腔科学)2013

    • Author(s)
      前田健康
    • Total Pages
      23-31
    • Publisher
      朝倉書店
  • [Book] 歯根膜の感覚機能(歯と歯列を守る歯根膜活用術)2011

    • Author(s)
      前田健康
    • Total Pages
      88-91
    • Publisher
      医歯薬出版

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Published: 2015-06-25  

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