2013 Fiscal Year Final Research Report
Development of a new comprehensive treatment for dental caries based on minimum intervention dentistry
| Project/Area Number |
23390435
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MATSUO Takashi 徳島大学, ヘルスバイオサイエンス研究部, 教授 (30173800)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Tadashi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (00217770)
SUGE Toshiyuki 徳島大学, 病院, 講師 (60243713)
YUMOTO Hiromichi 徳島大学, 病院, 講師 (60284303)
HIRAO Kouji 徳島大学, 病院, 助教 (00581399)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 齲蝕 / 歯髄炎 / ミニマムインターベンション / 高周波/電磁波 / アンモニウムヘクサフルオロシリケート |
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| Research Abstract |
In Japan, challenging cases of dental disease such as root surface caries become a problem in step with a rapid aging society. We tried to develop a new comprehensive treatment of caries based on minimum intervention. First, we developed the remineralization and reinforcement of decalcified tooth using ammonium hexafluorosilicate (SiF) with antimicrobial agents. Second, we developed the disinfection of caries related bacteria with electro-magnetic wave irradiation (EMWI). And finally, we examined the anti-inflammatory effects of tea catechin to fibroblasts to develop a new treatment for deep carious lesion.
We found the increase of crystallinity of hydroxyapatite with SiF treatment and antibacterial agents such as catechin are effective with SiF. Also, we found the bacteriocidal or inactive effects of EMWI on S. mutans. Catechin had inhibited the production of cytokines and chemokines from pulpal fibroblasts.
These results indicate the possibility of new caries treatment.
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[Presentation] 高周波・電磁波照射を歯内療法に応用した症例2011
Author(s)
湯本浩通, 富永敏彦, 柴田眞吾, 武川大輔, 高橋加奈子, 木村智子, 平尾功治, 松尾敬志
Organizer
第134回日本歯科保存学会2011年度春期学術大会
Place of Presentation
東京ベイ舞浜ホテルクラブリゾート(千葉県)
Year and Date
20110609-10
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