Development of novel strategy for caries treatment based on techniques of dentin remineralization and regeneration

2014 Fiscal Year Final Research Report

• Project/Area Number: 23390436
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: SAITO TAKASHI 北海道医療大学, 歯学部, 教授 (40265070)
• Co-Investigator(Kenkyū-buntansha): ITO Shuichi 北海道医療大学, 歯学部, 准教授 (50382495) ; BESSHO Kazuhisa 京都大学, 医学研究科, 教授 ; HANDA Keisuke 北海道医療大学, 歯学部, 講師 (40433429)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 保存修復学 / 齲蝕治療 / 象牙質再石灰化 / 修復象牙質誘導

Outline of Final Research Achievements

The results of this research having the purpose of developing novel caries treatment materials, method based on dentin remineralization technology and dentin regeneration technology are as follows; Firstly, the mineral induction ability of CMET was confirmed and the high remineralization activity and the long-term durability at the adhesion interface of CMET containing adhesive materials were clarified. Furthermore, it was demonstrated that phosphohporyn RGD-peptides promoted odontoblast-differentiation in vitro and the reparative dentin formation in vivo. From these results, it was suggested the high possibility of these materials as novel caries treatment materials.

Free Research Field

歯科保存学