2013 Fiscal Year Final Research Report
Application of bone conductive DNA/protamine complex for injectable bone graft materials
| Project/Area Number |
23390455
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Fukuoka Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Minoru 福岡歯科大学, 口腔歯学部, 講師 (10122780)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNO Jun 福岡歯科大学, 口腔歯学部, 講師 (10152208)
DOI Yutaka 朝日大学, 歯学部, 教授 (40116067)
HAYAKAWA Tohru 鶴見大学, 歯学部, 教授 (40172994)
OKAHATA Yoshio 山形大学, 大学院・理工学研究科, 教授 (80038017)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | DNA / プロタミン / 複合体 / 骨補填材 / インジェクション / 骨形成 / ペースト / 骨伝導性 |
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| Research Abstract |
The DNA/protamine complex was prepared by reaction between salmon tests DNA and protamine in order to investigate the potentials of the complex for injectable bone graft materials. The complex became paste by kneading the complex powder and distilled water, and the paste upgrade the expression of bone-related genes. Moreover, the paste induced new bone formation in rat cranial defect. Therefore, the DNA/protamine complex paste will be a useful biomaterial for injectable bone graft material.
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