2013 Fiscal Year Final Research Report
Optimization of the bone regeneration system using small molecules and examination of its molecular mechanisms
| Project/Area Number |
23390460
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAIJO Hideto 東京大学, 医学部附属病院, 講師 (80372390)
OGASAWARA Toru 東京大学, 医学部附属病院, 講師 (20359623)
MORI Yoshiyuki 東京大学, 医学部附属病院, 准教授 (70251296)
TEI Yuichi 東京大学, 工学系研究科, 教授 (30345053)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 骨再生 |
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| Research Abstract |
This study is aimed to obtain basic knowledge on the bone regenerative therapy in which the shape and amount of regenerated bones are controlled by osteogenic small molecules. Optimization of osteogenic small molecule-based bone formation revealed that several small molecules efficiently induced osteoblast differentiation. Mechanistic studies proposed that their modes of action were the cell fate specification into an osteoblast lineage and the subsequent osteoblast maturation. Local administration of the molecules into bone defect models achieved bone regeneration in animals. Thus, these findings will lead to the development of small molecule-based bone regenerative therapies.
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[Journal Article] Implantation of tetrapod-shaped granular artificial bones or β-tricalcium phosphate granules in a canine large bone-defect model2014
Author(s)
Choi S, Liu I, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Chung UI, Sasaki N, Mochizuki M
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Journal Title
J Vet Med Sci
Volume: 76(2)
Pages: 229-235
Peer Reviewed
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[Journal Article] Cranioplasty with custom-made artificial bone after resection of multilobular bone tumor in a dog2014
Author(s)
Choi S, Honnami M, Liu I, Yamamoto K, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M
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Journal Title
J Vet Clin
Volume: 31(1)
Pages: 46-50
Peer Reviewed
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[Journal Article] Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped granular artificial bones and basic fibroblast growth factor-binding ion complex gel2013
Author(s)
Honnami M, Choi S, Liu I, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M
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Journal Title
Biomaterials
Volume: 34(36)
Pages: 9056-9062
Peer Reviewed
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[Journal Article] Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium2013
Author(s)
Hojo H, Ohba S, Taniguchi K, Shirai M, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI
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Journal Title
J Biol Chem
Volume: 288(14)
Pages: 9924-9932
Peer Reviewed
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[Journal Article] Gli1 protein participates in the hedgehog-mediated specification of the osteoblast lineage during endochondral ossification2012
Author(s)
Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI
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Journal Title
J Biol Chem
Volume: 287(21)
Pages: 17860-69
Peer Reviewed
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[Journal Article] Bone regeneration by the combined use of tetrapod-shaped calcium phosphate granules with basic fibroblast growth factor-binding ion complex gel in canine segmental radial defects
Author(s)
Honnami M, Choi S, Liu IL, KamimuraW, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M
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Journal Title
J Vet Med Sci
Volume: (in press)
Peer Reviewed
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[Presentation] Gli1 Participates in the Indian Hedgehog-mediated Osteogenesis during Endochondral Ossification2012
Author(s)
Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata H, Suzuki K, Takato T, Kawaguchi H, Chung UI
Organizer
34th Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
Minneapolis, MN, USA (Travel Award)
Year and Date
20121000
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[Presentation] Development of a Novel Tetrapod-shaped Drug-eluting Artificial Bone2012
Author(s)
Maeda Y, Ohba S, Hojo H, Shimohata N, Yano F, Yamamoto K, Hatano N, Takato T, Chung UI
Organizer
34th Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
Minneapolis, MN, USA
Year and Date
20121000
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[Presentation] Osteo-chondrogenic Function of BMP is Directed Toward Osteogenesis by Hh-Gli1 in the Perichondrium2012
Author(s)
Hojo H, Ohba S, Taniguchi K, Shirai M, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI
Organizer
34th Annual Meeting of the American Society for Bone and Mineral Research
Place of Presentation
Minneapolis, MN, USA
Year and Date
20121000
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