2013 Fiscal Year Final Research Report
Production and Evaluation of artificial oral tossue stem cells applied cell reprogramming
| Project/Area Number |
23390470
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Takayoshi 大阪大学, 大学院・歯学研究科, 教授 (90379082)
YAMADA Aya 東北大学, 大学院・歯学研究科, 準教授 (40295085)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 幹細胞 / 口腔組織 / 歯髄 |
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| Research Abstract |
The aim of this research is the application of multipotent stem cells artificially induced from tissue cells to regenerative medicine.
We revealed that GSK3b inhibitor IX induced tooth pulp cells to pulp stem cells, and mediated marker of stem cell. As a result of the transplantation of induced pulp stem cell derived from human deciduous teeth to subcutaneous of mouse using hydroxyapatite as a carrier, hydroxyapatite was absorbed completely and produced substantial bone tissue included human derived blood cells. These results are the innovative discovery that artificial induction of tissue stem cells generated human bone marrow, and the method is expected as the applicable technique for the treatment of blood disorder such as leukemia.
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Research Products
(6 results)
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[Journal Article] Role of epithelial-stem cell interactions during dental cell differentiation2012
Author(s)
Arakaki M, Ishikawa M, Nakamura T, Iwamoto T, Yamada A, Fukumoto E, Saito M, Otsu K, Harada H, Yamada Y, Fukumoto S
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Journal Title
J Biol Chem
Volume: 287(13)
Pages: 10590-601
DOI
Peer Reviewed
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[Journal Article] IL-12 and IL-18-mediated, nitric oxide-induced apoptosis in TNF-a-mediated osteoclastgenesis of bone marrow cells2011
Author(s)
Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fuumoto E, Masuyama R, Yoshida N, Takano-Yamamoto T
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Journal Title
Calcif Tissue Int
Volume: 98(1)
Pages: 65-73
DOI
Peer Reviewed
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