2013 Fiscal Year Final Research Report
Screening of novel malaria vaccine candidates with protective immune sera
| Project/Area Number |
23406007
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Ehime University |
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Principal Investigator |
TSUBOI Takafumi 愛媛大学, プロテオサイエンスセンター, 教授 (00188616)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEO Satoru 杏林大学, 医学部, 准教授 (40302666)
TAKASHIMA Eizo 愛媛大, プロテオサイエンスセンター, 准教授 (50366762)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 原虫 / マラリア / ワクチン / プロテインアレイ / パプアニューギニア / 国際研究者交流 |
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| Research Abstract |
To identify novel malaria vaccine candidates, we first obtained serum samples from the children enrolled in the malaria cohort study in Papua New Guinean. We then established a micro-scale immunoscreening system for high-throughput detection of antigen-antibody reaction. Genome-widely expressed 1,900 parasite proteins by the wheat germ cell-free system covering one-third of the parasite genome were screened by using the immunoscreening system. As a result of the preliminary screening, we identified 650 immunoreactive proteins with the malaria immune serum samples which we previously had enough amount. The result suggests that this screening system would be effective to discover novel malaria vaccine candidates by using Papua New Guinean serum samples.
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[Journal Article] A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut2013
Author(s)
Mathias DK, Pastrana-Mena R, Ranucci E, Tao D, Ferruti P, Ortega C, Staples GO, Zaia J, Takashima E, Tsuboi T, Borg NA, Verotta L, Dinglasan RR
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Journal Title
PLoS Pathog
Volume: 9(11)
Pages: e1003757
DOI
Peer Reviewed
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